| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | GeneticVariation | disease | BEFREE | Although DRB1*1502, which differs from DRB1*1501 by a single amino acid, was not a risk allele for primary membranous nephropathy (odds ratio 1.01), it was associated with significantly lower estimated glomerular filtration rates both at baseline (1.79, 1.18-2.72) and at last follow-up (1.72, 1.17-2.53), a significantly worse renal outcome by Kaplan-Meier analysis and a significantly higher risk of end-stage renal disease by Cox regression analysis (hazard ratio 4.52, 1.22-16.74). | 30173899 | 2018 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | The discussed study identifies a novel allele, HLA DRB1*1502, in a Han Chinese cohort that acts as a modifier allele by associating not with the phenotype of membranous nephropathy, but rather with the severity of disease. | 30348302 | 2018 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | PLA2R-associated MN was initially found to associate with risk alleles within <i>HLA-DQA1</i>, but subsequent studies have shifted the focus to the HLA-DRB locus. | 28674044 | 2017 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | Classical HLA alleles (DRB1*0301-DQA1*0501-DQB1*0201 haplotype) were associated with MN but provided little additional information beyond rs9272729. | 27333618 | 2017 | ||||
|
0.370 | Biomarker | disease | BEFREE | HLA-DRB1*15:01 and HLA-DRB3*02:02 in PLA2R-Related Membranous Nephropathy. | 28028136 | 2017 | ||||
|
0.370 | Biomarker | disease | BEFREE | Different HLA-DR2 alleles were associated with different pathologic subtypes of HBV-GN: DRB1*1502 with membranoproliferative glomerulonephritis (MPGN, n = 35) (OR = 14.5) and DRB1*1501 with membranous nephropathy (MN, n = 11) (OR = 3.8). | 14617034 | 2003 | ||||
|
0.370 | Biomarker | disease | CTD_human | HLA-DRB1*0301 and DQA1*0501 in RA. | 11436868 | 2001 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | HLA-DRB and -DQB1 alleles in Polish patients with hepatitis B associated membranous nephropathy. | 9756401 | 1998 |