| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | AlteredExpression | disease | BEFREE | Myo-inositol treatment ameliorated the decreased expression of ZO-1 and synaptopodin in an in vitro FSGS model, and as myo-inositol increased, myo-inositol oxygenase tissue expression decreased proportionally to eGFR. | 31605028 | 2019 | ||||
|
0.370 | AlteredExpression | disease | BEFREE | For the FSGS group, the rate of renal function decline significantly correlated with baseline urinary synaptopodin mRNA levels (r = -0.496, p = 0.012). | 26308082 | 2015 | ||||
|
0.370 | AlteredExpression | disease | BEFREE | Compared with normal glomeruli, fewer cells stained for APOL1 in FSGS and HIVAN glomeruli, even when expression of the podocyte markers GLEPP1 and synaptopodin appeared normal. | 21997392 | 2011 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | So we presumed that the ACTN4 and SYNPO promoter mutations might also contribute to pathophysiology of idiopathic FSGS. | 19666657 | 2010 | ||||
|
0.370 | Biomarker | disease | GENOMICS_ENGLAND | So we presumed that the ACTN4 and SYNPO promoter mutations might also contribute to pathophysiology of idiopathic FSGS. | 19666657 | 2010 | ||||
|
0.370 | Biomarker | disease | BEFREE | Moreover, bigenic heterozygosity for synaptopodin and CD2AP is sufficient to induce spontaneous proteinuria and focal segmental glomerulosclerosis-like glomerular damage in mice. | 17569780 | 2007 | ||||
|
0.370 | AlteredExpression | disease | LHGDN | We investigated the association between expression of synaptopodin and glomerular epithelial protein 1 (GLEPP1) and response to corticosteroid therapy in primary FSGS. | 16564554 | 2006 | ||||
|
0.370 | Biomarker | disease | BEFREE | Combinations of Cd2ap heterozygosity and heterozygosity of either synaptopodin (Synpo) or Fyn proto-oncogene (Fyn) but not kin of IRRE like 1 (Neph1) resulted in spontaneous proteinuria and in FSGS-like glomerular damage. | 16628251 | 2006 |