Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6862
Gene Symbol: TBXT
TBXT
0.010 Biomarker phenotype BEFREE Our findings suggest that patients with goiter (diffused or toxic) have association of TFT'S and BMI with serum electrolytes and creatinine , I131 therapy is also associated with the increase in creatinine and chloride levels of patients leading to kidney problems. 31465286 2020
Entrez Id: 53919
Gene Symbol: SLCO1C1
SLCO1C1
0.010 Biomarker phenotype BEFREE Notably, oatp1c1-/- and oatp1c1-/-Xmct8-/- adults exhibit an enlarged thyroid gland (goiter). 31797746 2020
Entrez Id: 250
Gene Symbol: ALPP
ALPP
0.010 Biomarker phenotype BEFREE In addition, dietary RSM inclusion levels induced liver enlargement in ducklings at day 21 (5 to 20% double-low RSM with 1.37 to 5.31 µmol/g GLS) and thyroid enlargement accompanied by increased serum AST and ALP activities in ducks at day 42 (5 to 15% Indian RSM with 7.67 to 23.66 µmol/g GLS). 31347686 2019
Entrez Id: 284403
Gene Symbol: WDR62
WDR62
0.010 AlteredExpression phenotype BEFREE The relative WDR62 mRNA expression was not statistically different in DTC tissues and goiter tissues (P = 0.686). 30884127 2019
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.010 Biomarker phenotype BEFREE In addition, dietary RSM inclusion levels induced liver enlargement in ducklings at day 21 (5 to 20% double-low RSM with 1.37 to 5.31 µmol/g GLS) and thyroid enlargement accompanied by increased serum AST and ALP activities in ducks at day 42 (5 to 15% Indian RSM with 7.67 to 23.66 µmol/g GLS). 31347686 2019
Entrez Id: 470
Gene Symbol: ATHS
ATHS
0.010 Biomarker phenotype BEFREE In addition, dietary RSM inclusion levels induced liver enlargement in ducklings at day 21 (5 to 20% double-low RSM with 1.37 to 5.31 µmol/g GLS) and thyroid enlargement accompanied by increased serum AST and ALP activities in ducks at day 42 (5 to 15% Indian RSM with 7.67 to 23.66 µmol/g GLS). 31347686 2019
Entrez Id: 84131
Gene Symbol: CEP78
CEP78
0.010 AlteredExpression phenotype BEFREE Our results demonstrated that relative CEP78 mRNA levels were significantly decreased in thyroid cancer tissues than goiter tissues (P = 0.002). 30884127 2019
Entrez Id: 6590
Gene Symbol: SLPI
SLPI
0.010 Biomarker phenotype BEFREE In addition, dietary RSM inclusion levels induced liver enlargement in ducklings at day 21 (5 to 20% double-low RSM with 1.37 to 5.31 µmol/g GLS) and thyroid enlargement accompanied by increased serum AST and ALP activities in ducks at day 42 (5 to 15% Indian RSM with 7.67 to 23.66 µmol/g GLS). 31347686 2019
Entrez Id: 26033
Gene Symbol: ATRNL1
ATRNL1
0.010 Biomarker phenotype BEFREE In addition, dietary RSM inclusion levels induced liver enlargement in ducklings at day 21 (5 to 20% double-low RSM with 1.37 to 5.31 µmol/g GLS) and thyroid enlargement accompanied by increased serum AST and ALP activities in ducks at day 42 (5 to 15% Indian RSM with 7.67 to 23.66 µmol/g GLS). 31347686 2019
Entrez Id: 55226
Gene Symbol: NAT10
NAT10
0.010 Biomarker phenotype BEFREE In addition, dietary RSM inclusion levels induced liver enlargement in ducklings at day 21 (5 to 20% double-low RSM with 1.37 to 5.31 µmol/g GLS) and thyroid enlargement accompanied by increased serum AST and ALP activities in ducks at day 42 (5 to 15% Indian RSM with 7.67 to 23.66 µmol/g GLS). 31347686 2019
Entrez Id: 27295
Gene Symbol: PDLIM3
PDLIM3
0.010 Biomarker phenotype BEFREE In addition, dietary RSM inclusion levels induced liver enlargement in ducklings at day 21 (5 to 20% double-low RSM with 1.37 to 5.31 µmol/g GLS) and thyroid enlargement accompanied by increased serum AST and ALP activities in ducks at day 42 (5 to 15% Indian RSM with 7.67 to 23.66 µmol/g GLS). 31347686 2019
Entrez Id: 10850
Gene Symbol: CCL27
CCL27
0.010 Biomarker phenotype BEFREE In addition, dietary RSM inclusion levels induced liver enlargement in ducklings at day 21 (5 to 20% double-low RSM with 1.37 to 5.31 µmol/g GLS) and thyroid enlargement accompanied by increased serum AST and ALP activities in ducks at day 42 (5 to 15% Indian RSM with 7.67 to 23.66 µmol/g GLS). 31347686 2019
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.010 Biomarker phenotype BEFREE The resulting areas under the receiver operating characteristic (ROC) curve were 0.78 for MGMT (d) for PTC versus goiter samples that can represent the overall ability of MGMT (d) methylation status to discriminate between PTC and goiter patients. 31127647 2019
Entrez Id: 113828
Gene Symbol: FAM83F
FAM83F
0.010 Biomarker phenotype BEFREE Moreover, TSH-induced goiter and <i>BRAF</i><sup><i>T</i>1799<i>A</i></sup> -induced PTC animal models also showed FAM83F activation. 30881348 2019
Entrez Id: 407007
Gene Symbol: MIR222
MIR222
0.010 AlteredExpression phenotype BEFREE miR-222 expression of the PTC group was significantly higher than that of the goiter group (P < .001). 31232941 2019
Entrez Id: 2934
Gene Symbol: GSN
GSN
0.010 Biomarker phenotype BEFREE iTRAQ analysis of urinary proteins: Potential use of gelsolin and osteopontin to distinguish benign thyroid goiter from papillary thyroid carcinoma. 29355489 2018
Entrez Id: 50507
Gene Symbol: NOX4
NOX4
0.010 Biomarker phenotype BEFREE Thus, the present study suggests that there is a relationship between the size of the goiter and NIS regulation and that the mechanism might involve I-X, TGFβ, NOX4 and increased ROS production. 29112772 2018
Entrez Id: 406992
Gene Symbol: MIR210
MIR210
0.010 Biomarker phenotype BEFREE In addition, serum miR-210 and miR-155 in GD were associated with the extent of goiter. 28569050 2018
Entrez Id: 406947
Gene Symbol: MIR155
MIR155
0.010 Biomarker phenotype BEFREE In addition, serum miR-210 and miR-155 in GD were associated with the extent of goiter. 28569050 2018
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.010 AlteredExpression phenotype BEFREE Amongst these, four proteins were further chosen for validation using immunoblotting, and the enhanced levels of osteopontin in BTG patients and increased levels of a truncated gelsolin fragment in PTC patients, relative to controls, appeared to corroborate the findings of the iTRAQ analysis. 29355489 2018
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
0.010 Biomarker phenotype BEFREE Consequently, GLIS3 deficiency in a murine model prevented the development of goiter as well as the induction of inflammatory and fibrotic genes during chronic elevation of circulating TSH. 29083325 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.010 AlteredExpression phenotype BEFREE The significantly higher expression of IL-2, IL-6, and TGF-β was mainly concentrated in the thyroid follicular cells of patients with hyperthyroidism and thyroid enlargement (p < 0.05). 29131274 2017
Entrez Id: 5741
Gene Symbol: PTH
PTH
0.010 AlteredExpression phenotype BEFREE To determine whether pre-operative serum 25-hydroxyvitamin D has an impact on post-operative parathyroid hormone and serum calcium levels in patients undergoing total thyroidectomy for benign goitre. 28874217 2017
Entrez Id: 27131
Gene Symbol: SNX5
SNX5
0.010 Biomarker phenotype BEFREE In comparison to wild-type (Snx5<sup>+/+</sup> ) mice, Snx5<sup>-/-</sup> mice showed enlarged thyroid glands that consisted of thyrocytes with large irregular-shaped vacuoles. 28771744 2017
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.010 AlteredExpression phenotype BEFREE The significantly higher expression of IL-2, IL-6, and TGF-β was mainly concentrated in the thyroid follicular cells of patients with hyperthyroidism and thyroid enlargement (p < 0.05). 29131274 2017