Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.360 | Biomarker | disease | BEFREE | CTLA-4 inhibition may be especially effective in treating late post-allogeneic stem cell transplant relapse of AML in patients with limited or no graft versus host disease. | 28679300 | 2018 | ||||
|
0.360 | GeneticVariation | disease | BEFREE | Here, we investigated FR104, an antagonistic CD28-specific pegylated-Fab', in the nonhuman primate (NHP) GVHD model and completed a multiparameter interrogation comparing it with CTLA4-Ig, with and without sirolimus, including clinical, histopathologic, flow cytometric, and transcriptomic analyses. | 30102255 | 2018 | ||||
|
0.360 | Biomarker | disease | BEFREE | These data suggest that increased expression of checkpoint blockade molecules PD-1 and CTLA-4 on donor T cells is not sufficient to prevent GvHD, and that cooperation between checkpoint blockade signaling by host cells and donor Tregs is necessary to limit GvHD in allo-HSCT recipients. | 28953925 | 2017 | ||||
|
0.360 | GeneticVariation | disease | BEFREE | After gender classification, there is a significant association between GA genotype (CTLA4-1661) in male group with GVHD than without GVHD (p=0.03). | 24564845 | 2014 | ||||
|
0.360 | GeneticVariation | disease | BEFREE | Polymorphisms on the CTLA-4 gene have been previously associated with autoimmune diseases, predisposition to leukemic relapse, and with graft-versus-host disease (GVHD) or relapse after allogeneic transplant. | 21703972 | 2012 | ||||
|
0.360 | GeneticVariation | disease | BEFREE | The aim of this study is to examine the effect of donor CTLA-4 alleles and haplotypes for the -318C>T and the 49A>G polymorphisms on the occurrence of GVHD in Tunisians recipients of HSCs. | 21081144 | 2011 | ||||
|
0.360 | Therapeutic | disease | CTD_human | Efficiency of adenoviral vector mediated CTLA4Ig gene delivery into mesenchymal stem cells. | 14642129 | 2003 |