|
HLA-DPB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nonpermissive HLA-DPB1 mismatches were not associated with a higher incidence of GvHD, but the incidence of relapse was higher in patients undergoing HSCT from HLA-DPB1-matched transplantations.
|
31850671 |
2020 |
|
HLA-DPB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Comparative evaluation of biological HLA-DPB1 mismatch models for survival and graft versus host disease prediction after unrelated donor hematopoietic cell transplantation.
|
31471374 |
2019 |
|
HLA-DPB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism in the 3' untranslated region of HLA-DPB1, rs9277534, is associated with HLA-DPB1 expression. rs9277534 has been linked to hepatitis B virus recovery/persistence and the risk of graft-versus-host disease with HLA-DPB1 mismatching transplantation of hematopoietic cells, but its role along with that of HLA-DP expression in AIH have not been fully clarified.
|
30093645 |
2018 |
|
HLA-DPB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The analysis did not reveal any significant influence of HLA-DPB1 alleles on overall survival (OS), non-relapse mortality (NRM) or graft-versus-host disease (GvHD) incidence.
|
28887054 |
2017 |
|
HLA-DPB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast to the assumption that mismatches in HLA-DRB3, 4, and 5 are not of immunogenic significance after HLA 10/10 matched allogeneic stem cell transplantation, we show that in this matched setting not only mismatches in HLA-DPB1, but also mismatches in HLA-DRB3 may induce a polyclonal allo-immune response associated with conversion of chimerism and severe GVHD.
|
28252558 |
2017 |
|
HLA-DPB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In contrast, the risks of GVHD-related outcomes were higher in HLA-DP GVH-mismatched unrelated recipients than in HLA-matched sibling recipients.
|
27872059 |
2017 |
|
HLA-DPB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mismatched HLA-DP is targeted by direct alloreactive T cell responses with important implications for graft-versus-host disease and graft-versus-leukemia.
|
28667011 |
2017 |
|
HLA-DPB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In further analyses, the recipient DPA1*01:03∼DPB1*04:01 haplotype and certain amino acid substitutions in the recipient P1 peptide-binding pocket of the HLA-DP heterodimer were associated with risk of sclerotic GVHD.
|
27313329 |
2016 |
|
HLA-DPB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
A significant RR of HLA allele mismatch compared with match was seen with HLA-A, -B, -C, and -DPB1 for grade III-IV acute graft-versus-host disease (GVHD), and HLA-C for chronic GVHD.
|
25519752 |
2015 |
|
HLA-DPB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We tested the hypothesis that the GVHD risk correlates with the rs9277534 allele linked to the mismatched HLA-DPB1 in the recipient.
|
26267621 |
2015 |
|
HLA-DPB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that HLA-DPB1 typing combined with a simple TNFd microsatellite genotyping assay may significantly help in pretransplantation risk assessment for graft-versus-host disease and mortality, particularly for patients with several potential 10 of 10 matched donors.
|
21963878 |
2012 |
|
HLA-DPB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this analysis of 5930 patient/donor pairs, we found that a DPB1 mismatch predicted significantly for an increased risk of acute graft-vs-host disease [hazard ratio (HR): 1.33; P-value = <0.0001], while protecting against disease relapse (HR: 0.82, P-value = 0.01).
|
17445160 |
2007 |
|
HLA-DPB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
DPB1 identity between donor and recipient was observed in 24% and DPB1 compatibility (GVHD vector) in 42%.
|
12379888 |
2002 |
|
HLA-DPB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
In DPB1 mismatched transplants an association between patient survival and matching for individual DPB1 polymorphic regions was not observed; however in the HLA-A, B, DRB1, DQA1, DQB1 allele matched transplants a non significant increase in the frequency of Grade IV GVHD was observed in recipients who were negative compared to those who were positive for DPB1 alleles coding for glutamic acid at position 69.
|
10408803 |
1999 |
|
HLA-DPB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
The role of HLA-DPB1 disparity in the development of acute graft-versus-host disease (GVHD) following unrelated donor (URD) marrow transplantation is unknown.
|
8461476 |
1993 |