Gene: IL17A ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.400 AlteredExpression disease BEFREE Furthermore, mice with clinical GVHD exhibited increases in the splenic human CD4<sup>+</sup>:CD8<sup>+</sup> T cell ratio, serum human interferon (IFN)-γ and intestinal human IL-17 expression compared to mice with subclinical GVHD. 30743002 2019
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.400 Biomarker disease BEFREE IL-17A Contributes to Lung Fibrosis in a Model of Chronic Pulmonary Graft-versus-host Disease. 31658231 2019
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.400 Biomarker disease BEFREE Furthermore, IL-17 reduced the infiltration of macrophages into the GVHD tissues. 27748733 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.400 Biomarker disease BEFREE hpMSCs reduced weight loss, along with IL-6 and IL-17 production to prolong the survival of GVHD mice. 30393022 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.400 AlteredExpression disease BEFREE In the clinic, high levels of both IL-17A and IL-22 expression are present in the skin of patients with GVHD after allo-SCT. 28941323 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.400 Biomarker disease BEFREE Allogeneic BMT recipients deficient in IL-17A also develop accelerated GVHD, suggesting MAIT cells likely regulate GVHD, at least in part, by the generation of this cytokine. 29629900 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.400 Biomarker disease BEFREE Donor T-cell-derived interleukin-17A (IL-17A) can mediate late immunopathology in graft-versus-host disease (GVHD), however protective roles remain unclear. 28137828 2017
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.400 Biomarker disease BEFREE Patients who developed GVHD were characterized by a predominant pro-inflammatory response (IL-17A (10.02 vs 0.43pg/mL, p=0.006), TNF-α (54.57 vs 0.81pg/mL, p=0.001)), in contrast to a deficient suppressor profile (IL-10 (7.87 vs 41.37pg/mL, p=0.003)) and Tregs (0.95% vs 1.52%, p=0.004). 29101827 2017
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.400 Biomarker disease BEFREE These results indicate that pathogenic human Th17 cells induce cutaneous GVHD via IL-17-dependent pathways. 27862942 2017
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.400 GeneticVariation disease BEFREE Association of IL-17 gene polymorphisms and serum level with graft versus host disease after allogeneic hematopoietic stem cell transplantation. 24968286 2014
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.400 Biomarker disease BEFREE Furthermore, upon ex vivo reisolation of transferred wild-type Treg, we detected little or no Treg-mediated IL-17 production upon GVHD induction. 23921175 2013
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.400 Biomarker disease CTD_human Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17. 22077062 2012