| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | disease | BEFREE | We evaluated the serum levels of IGF-1 in patients with hyperthyroidism or euthyroidism.In this study, 30 patients each of Graves' disease with hyperthyroidism (HY group) and euthyroid individuals (EU group) were recruited. | 30882687 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | In addition, antibodies against IGF-IR have been detected in patients with Graves' disease and in rodent models of TAO. | 30385883 | 2019 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Graves' ophthalmopathy (GO) is a complication of Graves' disease (GD), in which orbital connective tissues become inflamed and increase in volume and orbital fibroblasts within the orbital fat and extraocular muscles differentiate into adipocytes in vitro when stimulated by hormones, several cytokines, and growth factors including TSH, IGF-1, IL-1, interferon γ, and platelet-derived growth factor. | 31399042 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | We evaluated the regulatory T (Treg) cell fractions induced with IGF-1 in Graves' disease (GD) with and without GO. | 28222462 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | Evidence for an association between thyroid-stimulating hormone and insulin-like growth factor 1 receptors: a tale of two antigens implicated in Graves' disease. | 18768899 | 2008 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Our findings suggest that thyrocytes can be activated by GD-IgG and IGF-I to express powerful T-cell chemoattractants. | 16410300 | 2006 | ||||
|
0.080 | Biomarker | disease | BEFREE | Moreover, GD-IgG displaces specific (125)I-labeled IGF-I binding to fibroblasts and attenuates IGF-IR detection by flow cytometry. | 12794168 | 2003 | ||||
|
0.080 | Biomarker | disease | BEFREE | The results of this study suggest that IGF-1 and IGF-1 receptor may be actively involved in the pathogenesis of Graves' disease; furthermore, IGF-1 and IGF-1 receptor apparently act by different mechanisms (paracrine vs. autocrine) as suggested by their differential expression in epithelial and stromal cells. | 9857239 | 1998 |