|
LINC01193
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the CTLA4 + 49 A/G and CT 60 A/G SNPs have a significant association with the risk of GD development in Kashmiri population and CTLA4 mRNA expression is significantly decreased in GD.
|
31708111 |
2020 |
|
LINC01193
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
*642AT(8_33)(AT<sub>16-21</sub>)/CT60(rs3087243)G/Jo31(rs11571302)G/ICOSc.1554+4GT(8_15)(m) and TCA(AT<sub><16</sub>)GT(m) haplotypes increased risk of Graves' disease, especially in males, as well as overall Graves' orbitopathy development with severe outcome.
|
27638540 |
2017 |
|
LINC01193
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Significant linkage disequilibrium was found between +49A/G and CT60 in GD and control subjects (D' = 0.92).
|
27111218 |
2016 |
|
LINC01193
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate whether a genetic combined effect exists between CD40-1C>T and CTLA-4+6230G>A (CT60) polymorphisms and whether the combined effect renders susceptibility to Graves' disease (GD).
|
25936345 |
2015 |
|
LINC01193
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A significant association was found between the CTLA-4 CT60 polymorphism (rs3087243) and GD, with regard to comparisons between allele and genotype frequencies (all p < 0.001).
|
24697361 |
2014 |
|
LINC01193
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, as to the -318C/T polymorphism and CT60 polymorphism, the results indicated that the variant allele carriers might have decreased risks of GD when compared with the homozygote carriers (-318C/T: TT+TC vs. CC: OR = 0.78, 95%CI = 0.62-0.97; CT60: AA+AG vs. GG: OR = 0.64, 95%CI = 0.52-0.78).
|
23597029 |
2013 |
|
LINC01193
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For a CTLA4 CT60 polymorphism, the antithyrotropin receptor antibody levels at the onset of GD were significantly higher in those with the GG genotype than in those with other genotypes (P = 0.0117).
|
22706687 |
2012 |
|
LINC01193
|
0.100 |
Biomarker
|
disease |
BEFREE |
CTLA-4 genotypes in exon 1 (A/G(49)) and CT60 were analyzed in 415 Japanese patients with Graves' disease and 65 patients with AATD.
|
19731979 |
2009 |
|
LINC01193
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Soluble CTLA-4 receptor an immunological marker of Graves' disease and severity of ophthalmopathy is associated with CTLA-4 Jo31 and CT60 gene polymorphisms.
|
19734241 |
2009 |
|
LINC01193
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In a comparison of frequencies of GG genotype, a significant association of 49A/G and CT60 polymorphism existed only for Graves' disease.
|
19559744 |
2009 |
|
LINC01193
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The recently described single nucleotide polymorphism CT60, located in the 3' untranslated region of CTLA4 is associated with Graves' disease, thyroiditis, autoimmune diabetes and other autoimmune diseases.
|
17942509 |
2008 |
|
LINC01193
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The CT60 GG genotype and G alleles were more prevalent in GD (P = 0.07 and P = 0.02, respectively).
|
18296657 |
2008 |
|
LINC01193
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In a Polish population the ESR2 A allele is associated with GD with a strength comparable to polymorphisms of PTPN22 and CTLA4 CT60 loci (OR approximately 1.7).
|
17941906 |
2008 |
|
LINC01193
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The CT60 SNP was associated with susceptibility to GD.The G allele increased the risk of GD.
|
18780601 |
2008 |
|
LINC01193
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Group-level data suggested significant associations with GD and HT for both A49G [odds ratios 1.49 (P = 6 x 10(-14)) and 1.29 (P = 0.001) per G allele, respectively] and CT60 [1.45 (P = 2 x 10(-9)) and 1.64 (P = 0.003) per G allele, respectively].
|
17504905 |
2007 |
|
LINC01193
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrated that both the +49A/G and CT60 polymorphisms were associated with GD susceptibility in the Chinese population.
|
16916658 |
2006 |
|
LINC01193
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results showed that there was no significant positive association between any individual SNP or haplotype comprising of the four 3 untranslated region (UTR) SNPs (CT60, JO31, JO30, and JO27-1) and GD.
|
16571085 |
2006 |
|
LINC01193
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results showed that either +49A/G or CT60 polymorphism was associated with GD susceptibility in the Chinese population.
|
16893393 |
2006 |
|
LINC01193
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Autoimmune diseases such as Graves' disease and type 1 diabetes have been linked with +49A/G and CT60 single nucleotide polymorphisms (SNPs) in the 3' UTR of the cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene.
|
16313305 |
2005 |
|
LINC01193
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the G allele of the CT60 was associated with the increased risk for GD [P=0.004, odds ratio (OR)=2.0] and AITD (P=0.03,OR=1.6) in a recessive model.
|
16040335 |
2005 |
|
LINC01193
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The G allele of A49G, the G allele of CT60, and the 280 allele of (AT)(n)-3'UTR microsatellite were significantly increased in patients with GD with thyroid-associated ophthalmopathy (TAO) compared to controls (p = 0.04, p = 0.03, and p = 0.02, respectively), however, we did not find any significant difference between TAO and non-TAO patients.
|
15785242 |
2005 |
|
LINC01193
|
0.100 |
Biomarker
|
disease |
BEFREE |
Subset analysis demonstrated no significant difference between the frequencies of HLA-DR3 and the susceptibility alleles of CTLA-4 A/G(49) and CT60 SNPs in the familial and sporadic GD subsets (P > 0.05).
|
15356063 |
2004 |