Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
0.560 GeneticVariation group BEFREE Plasma NTproANP, NTproBNP and NTproCNP and their bioactive counterparts were measured in a random sample of 348 community dwellers aged 49-51 yr without heart disease and associations sought with established vascular risk factors, echocardiographic indices and a genetic variant previously linked with BNP. 31431677 2019
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
0.560 GeneticVariation group BEFREE Plasma samples for BNP measurement were repeated in 29 patients (63 ± 11 years) who were alive at 5 years after radiotherapy, free of heart disease and available to provide new blood sample. 30431375 2019
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
0.560 Biomarker group BEFREE On the contrary, established proteomic technologies, together with the new alternative strategies currently under evaluation (i.e. metabolomics), are now making possible the translation of data obtained on the bench to the daily clinical routine with the discovery of new diagnostic/prognostic biomarkers (such as troponin for ACS and BNP for congestive heart failure) and the identification of new therapeutic approaches for combating heart diseases. 19449458 2009
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
0.560 Biomarker group LHGDN B-type natriuretic peptide for diagnosis and therapy. 18537757 2008
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
0.560 Biomarker group CTD_human Brain natriuretic peptide as a marker of cardiac toxicity in patients with multiple sclerosis treated with mitoxantrone. 18004637 2008
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
0.560 AlteredExpression group LHGDN Plasma brain natriuretic peptide levels in normotensive Type 2 diabetic patients without cardiac disease and macroalbuminuria. 12015190 2002
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
0.560 Biomarker group LHGDN Clinical significance of blood brain natriuretic peptide level measurement in the detection of heart disease in untreated outpatients: comparison of electrocardiography, chest radiography and echocardiography. 11999635 2002
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
0.560 Biomarker group RGD Opposite regulation of brain and C-type natriuretic peptides in the streptozotocin-diabetic cardiopathy. 10828832 2000
Entrez Id: 7076
Gene Symbol: TIMP1
TIMP1
0.510 Biomarker group BEFREE In non-COPD, male sex, age, burden of smoking, heart disease and MMP-9/TIMP-1 ratio were associated with increased risk for death, while increased TIMP-1 was protective. 29650051 2018
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.510 Biomarker group BEFREE Cardiac function appears to be unimpaired in Darier disease patients, with no evidence that SERCA2 haploinsufficiency itself causes heart disease. 26064889 2015
Entrez Id: 7076
Gene Symbol: TIMP1
TIMP1
0.510 Biomarker group CTD_human Genomic biomarkers for cardiotoxicity in rats as a sensitive tool in preclinical studies. 23558518 2013
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.510 Biomarker group RGD Abnormal amounts of intracellular calcium regulatory proteins in SHRSP.Z-Lepr(fa)/IzmDmcr rats with metabolic syndrome and cardiac dysfunction. 23458196 2013
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.510 Biomarker group CTD_human Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. 19328205 2009
Entrez Id: 7076
Gene Symbol: TIMP1
TIMP1
0.510 Biomarker group RGD [The effect of bone marrow mesenchymal stem cell transplantation on diabetic cardiomyopathy]. 19134282 2008
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.380 Biomarker group BEFREE BMI >45 kg/m<sup>2</sup> was associated with higher prevalence of hypertension, systolic and diastolic blood pressure, C-reactive protein, waist circumference, body fat % and family history of heart diseases, enhancing the risk for the occurrence of cardiovascular diseases. 31791637 2020
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.380 AlteredExpression group BEFREE Prognosis of myocardial infarction tends to be worse when serum C-reactive protein (CRP) level is high. miRNAs are also known to be involved in different pathogeneses of heart diseases such as myocardial infarction. 31063484 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.380 Biomarker group BEFREE The rich expression of antimicrobial peptides and its association with CRP support the idea that an inflammatory process is involved in the pathogenesis of acquired heart diseases. 30734265 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.380 Biomarker group BEFREE Statins have antiinflammatory effects and are known to decrease risk of cardiovascular events and to reduce serum levels of C-reactive protein (CRP), a widely studied biomarker and potential mediator of inflammation and heart disease. 24410968 2014
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.380 GeneticVariation group BEFREE Genetic predisposition to high baseline CRP might account for a high risk of heart diseases. 22828776 2012
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.380 Biomarker group BEFREE C-reactive protein promotes cardiac fibrosis and inflammation in angiotensin II-induced hypertensive cardiac disease. 20157054 2010
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.380 Biomarker group CTD_human Elevation of C-reactive protein (CRP) levels in blood was recognized as one of the cardiac disease risk factors. 17388968 2007
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.380 Biomarker group BEFREE The basic mechanisms responsible for this association are not clear; CRP may merely be a marker of inflammation with no specific role in the pathogenesis of cardiac disease or may directly modulate the disease process. 12237169 2002
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.380 GeneticVariation group BEFREE Elevation of baseline C-reactive protein (CRP) is associated with increased risk of cardiac disease. 11857055 2002
Entrez Id: 183
Gene Symbol: AGT
AGT
0.370 Biomarker group BEFREE Angiotensin II-related cardiac fibrosis is one of the key pathological changes of the hypertrophied left ventricle in various heart disease. 30703374 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.370 AlteredExpression group BEFREE Elevated angiotensin II (Ang II) and sympathetic activity contributes to a high risk of ventricular arrhythmias in heart disease. 28941256 2017