Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.510 Therapeutic phenotype RGD Curcumin inhibits cardiac hypertrophy and improves cardiovascular function via enhanced Na 29331788 2018
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.510 Biomarker phenotype CTD_human PPARα activation inhibits endothelin-1-induced cardiomyocyte hypertrophy by prevention of NFATc4 binding to GATA-4. 22198280 2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.510 GeneticVariation phenotype LHGDN Gene polymorphisms predisposing to cardiac hypertrophy in patients with cardiac syndrome X. 19051693 2007
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.510 GeneticVariation phenotype LHGDN Screening of the endothelin1 gene (EDN1) in a cohort of patients with essential left ventricular hypertrophy. 17335511 2007
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.510 Biomarker phenotype RGD Increased expression of endothelial nitric oxide synthase and caveolin-1 in the aorta of rats with isoproterenol-induced cardiac hypertrophy. 17487232 2006
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.510 Biomarker phenotype CTD_human Increased expression of endothelial nitric oxide synthase and caveolin-1 in the aorta of rats with isoproterenol-induced cardiac hypertrophy. 17487232 2006
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.510 Therapeutic phenotype CTD_human Increased expression of endothelial nitric oxide synthase and caveolin-1 in the aorta of rats with isoproterenol-induced cardiac hypertrophy. 17487232 2006
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.510 Biomarker phenotype CTD_human Low-dose simvastatin improves survival and ventricular function via eNOS in congestive heart failure. 16844920 2006
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.510 Therapeutic phenotype CTD_human Low-dose simvastatin improves survival and ventricular function via eNOS in congestive heart failure. 16844920 2006
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.510 Biomarker phenotype CTD_human Overexpression of endothelial nitric oxide synthase attenuates cardiac hypertrophy induced by chronic isoproterenol infusion. 12224825 2002
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.510 Therapeutic phenotype CTD_human Overexpression of endothelial nitric oxide synthase attenuates cardiac hypertrophy induced by chronic isoproterenol infusion. 12224825 2002
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.510 Therapeutic phenotype CTD_human Adeno-associated virus-mediated transfer of endothelial nitric oxide synthase gene inhibits protein synthesis of rat ventricular cardiomyocytes. 11504159 2001
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.510 Biomarker phenotype CTD_human Adeno-associated virus-mediated transfer of endothelial nitric oxide synthase gene inhibits protein synthesis of rat ventricular cardiomyocytes. 11504159 2001
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.510 ModifyingMutation phenotype RGD Endothelin-1 and its binding sites are upregulated in pressure overload cardiac hypertrophy. 7771559 1995
Entrez Id: 183
Gene Symbol: AGT
AGT
0.500 Biomarker phenotype CTD_human Ablation of aryl hydrocarbon receptor promotes angiotensin II-induced cardiac fibrosis through enhanced c-Jun/HIF-1α signaling. 31016362 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.500 Biomarker phenotype CTD_human Irisin attenuates angiotensin II-induced cardiac fibrosis via Nrf2 mediated inhibition of ROS/ TGFβ1/Smad2/3 signaling axis. 30703374 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.500 Therapeutic phenotype CTD_human Ablation of aryl hydrocarbon receptor promotes angiotensin II-induced cardiac fibrosis through enhanced c-Jun/HIF-1α signaling. 31016362 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.500 Therapeutic phenotype CTD_human Irisin attenuates angiotensin II-induced cardiac fibrosis via Nrf2 mediated inhibition of ROS/ TGFβ1/Smad2/3 signaling axis. 30703374 2019
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.500 Therapeutic phenotype RGD Pharmacological inhibition of DNA methylation attenuates pressure overload-induced cardiac hypertrophy in rats. 29792884 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.500 Therapeutic phenotype CTD_human Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway. 29353218 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.500 Biomarker phenotype CTD_human Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway. 29353218 2018
Entrez Id: 9464
Gene Symbol: HAND2
HAND2
0.500 Biomarker phenotype CTD_human A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart. 29394407 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.500 Therapeutic phenotype CTD_human SIRT4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity. 27099261 2017
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
0.500 Therapeutic phenotype RGD Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats. 27847271 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.500 Biomarker phenotype CTD_human SIRT4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity. 27099261 2017