Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease BEFREE The target of the current study was to examine the possible cardioprotective effect of telmisartan (Tel), an angiotensin II type 1 receptor (AT1R) blocker, compared with that of captopril (Cap), an angiotensin converting enzyme (ACE) inhibitor, in ameliorating PRG-induced HF in rats by assessing morphometric, echocardiographic and histopathological parameters. 31629013 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease BEFREE In this paper, we review the recent advances in the field of β-arrestin signaling of the AT1R, emphasizing its role in cardiovascular regulation and heart failure. 31447777 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 GeneticVariation disease BEFREE Meta-analysis showed significant associations between rs5186 in AGTR1 and increased rates by 25-34% for the primary endpoint (composite of death or nonfatal myocardial infarction, hospitalization for unstable angina, heart failure or peripheral vascular event), all-cause mortality, cardiovascular mortality and heart failure; all P < 0.001. 29982608 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression disease BEFREE The Chinese herbal formula SNT could improve left ventricular systolic function in heart failure after myocardial infarction in rats and decreased the level of Plasma Renin, Angiotensin II, and Aldosterone, as well as downregulating the protein and gene level of ACE and AT1R. 30050591 2018
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease BEFREE We compared the effects of sudden stretch to SFR as well as to twitch and Ca2+ transient characteristics in rat myocardium with monocrotaline-induced heart failure with those in normal rat myocardium without and with inhibition of angiotensin II type-1 (AT1) receptors. 29593122 2018
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 GeneticVariation disease BEFREE A prospective study of the impact of AGTR1 A1166C on the effects of candesartan in patients with heart failure. 29701105 2018
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 GeneticVariation disease BEFREE Thus, sensitization of the heart failure-promoting AT1 receptor by the RKIP-GRK2 interaction contributes to heart failure whereas dominant-negative GRK2-K220R is cardioprotective. 30687708 2018
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease BEFREE These findings indicate that females are more susceptible to the adverse effects of AT1R stimulation than males favouring the development of HF and increased mortality. 29343862 2018
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression disease BEFREE In the heart failure treated with intracerebroventricular (ICV) infusion of angiotensin II type 1 receptor blocker (ARB), sympathetic activation and brain oxidative stress were significantly lower, and baroreflex sensitivity and volume tolerance were significantly higher than in heart failure treated with vehicle. 29495326 2018
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease BEFREE AT1 receptor blocker azilsartan medoxomil normalizes plasma miR-146a and miR-342-3p in a murine heart failure model. 27321284 2017
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression disease BEFREE Intracellular Ang-II and nuclear AT1R protein levels were significantly increased in a heart failure model in which atrial fibrosis underlies atrial fibrillation. 28381466 2017
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 GeneticVariation disease BEFREE In conclusion, this meta-analysis suggests that the A1166C polymorphism in AT1R may not be associated with susceptibility to HF. 26345849 2015
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease BEFREE These data suggest that the serum levels of ghrelin are significantly positively correlated with Ang II in CHF patients and that ghrelin can inhibit Ang II-induced cardiomyocyte apoptosis by down-regulating AT1R, thereby playing a role in preventing HF. 24465706 2014
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Therapeutic disease RGD The protective effects of telmisartan and losartan in ADR-induced heart failure may be partially due to regulation of circulating Ang-(1-7) and myocardial AT(1)R expression. 21963897 2011
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 GeneticVariation disease BEFREE We genotyped 134 patients with HF and reduced systolic function for the AT1R A1166C genotype using polymerase chain reaction and restriction fragment length polymorphism. 18612202 2009
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease BEFREE Heart failure-related genes, such as brain natriuretic peptide, connective tissue growth factor and osteopontin; calcium signaling-related genes, such as ryanodine receptor 2, sarcoendoplasmic reticulum Ca(2+)-ATPase 2A2 and adenylate cyclase 7; renin-angiotensin system-related genes, such as angiotensinogen, angiotensin II receptor, type 1 and type 2; and mitochondria-related genes, such as peroxisome proliferator-activated receptor-gamma co-activator-1alpha, cytochrome c and transcription factor A mitochondrial, were significantly changed at the apical ventricle rather than at the basal ventricle. 19300450 2009
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease CTD_human Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone. 18586661 2008
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 GeneticVariation disease BEFREE The results of this proof-of concept study provide the first evidence that the AGTR1 A1166C polymorphism could influence the response to candesartan in patients with heart failure who are receiving ACE inhibitors. 18594050 2008
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease CTD_human Blockade of angiotensin II type 1 receptor (AT1) signaling attenuates heart failure following myocardial infarction (MI), perhaps through reduction of fibrosis in the noninfarcted myocardium. 17208988 2007
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease CTD_human Comparison of the cardioprotective effects of cardos and losartan in rats with experimental chronic cardiac insufficiency. 18214293 2007
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression disease LHGDN Gene polymorphism of angiotensin-converting enzyme and angiotensin II type 1 receptor in patients with congestive heart failure. 18767410 2007
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 GeneticVariation disease BEFREE Here we demonstrate that a polymorphism in the AT1R gene (A1166C), linked to increased receptor activity, is associated with elevated levels of oxidative stress markers in heart failure patients but not in healthy controls. 16651460 2006
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease BEFREE In conclusion, the diminished angiotensin II vasoconstriction with age in heart failure patients is most likely due to a lower density of AT(1) receptors and may result from a longer period of exposure to heart failure in older patients. 15569271 2004
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression disease LHGDN [Gene expression of Ang II receptors in myocardium in congestive heart failure]. 12133421 2002
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression disease BEFREE In human ventricles (n=13), message levels of atrial natriuretic peptide and AT(1) receptor were inversely correlated, which suggests a decrease in AT(1) receptor expression with progressive heart failure. 10715259 2000