Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.380 | Biomarker | disease | BEFREE | High plasma levels of homocysteine (Hcy) are regarded as a risk factor for atrial fibrillation (AF), which is closely associated with the pathological consequence of atrial fibrosis and can lead to heart failure with a high mortality rate; here, we show that atrial fibrosis is mediated by the relationship between canonical transient receptor potential 3 (TRPC3) channels and sirtuin type 1 (SIRT1) under the stimulation of Hcy. | 31680473 | 2020 | ||||
|
0.380 | Biomarker | disease | BEFREE | Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca<sup>2+</sup>-ATPase in Heart Failure. | 30786847 | 2019 | ||||
|
0.380 | Biomarker | disease | BEFREE | Sirt1/p53/Drp1dependent mitochondrial fission may be a valuable therapeutic target for hypertension induced heart failure. | 29593530 | 2018 | ||||
|
0.380 | AlteredExpression | disease | BEFREE | Overall, our data demonstrate that Smad2/3 is a specific SIRT1 target and suggests that pharmacological activation of SIRT1 may be a novel therapeutic strategy to prevent/reverse HF via modifying Smad activity. | 29800064 | 2018 | ||||
|
0.380 | Biomarker | disease | BEFREE | SIRT1 agonist resveratrol was used to treat the doxorubicin-induced heart failure mouse model. | 25766524 | 2015 | ||||
|
0.380 | AlteredExpression | disease | BEFREE | SIRT1 mRNA expression was significantly downregulated in HF with more robust decrease in dHF (p=0.002, control vs cHF; p<0.001, control vs dHF). | 26233702 | 2015 | ||||
|
0.380 | Therapeutic | disease | CTD_human | Heart failure was produced by myocardial infarction, and was associated with markedly increased AMPK and SIRT1 protein levels. | 24535859 | 2014 | ||||
|
0.380 | Biomarker | disease | BEFREE | Here, we provide additional lines of evidence supporting the pathological involvement of the PPARα/Sirt1 complex in heart failure. | 22333581 | 2012 | ||||
|
0.380 | Biomarker | disease | BEFREE | The purpose of this study was to investigate the functional role of SIRT1 in the heart and the potential use of SIRT1 in therapy for heart failure. | 20089851 | 2010 |