| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.270 | AlteredExpression | disease | BEFREE | Sin significantly improved stress load-induced heart failure (P < 0.05), reduced the heart-lung mass ratio, ANP, collagen-I and -III mRNA and protein levels (P < 0.05); Sin can enhance the ratio of IL-10/IL-17. | 31736093 | 2020 | ||||
|
0.270 | AlteredExpression | disease | BEFREE | We demonstrated an inverse clinical correlation between heart IL-17A levels and efferocytic receptor expressions in humans with heart failure (HF). | 31269438 | 2019 | ||||
|
0.270 | Biomarker | disease | BEFREE | Impact of cardiac resynchronization therapy on circulating IL-17 producing cells in patients with advanced heart failure. | 30483979 | 2019 | ||||
|
0.270 | AlteredExpression | disease | BEFREE | The expression of IL-17 and its downstream target genes may play fundamental roles in inducing VA in ischemic HF. | 30096409 | 2018 | ||||
|
0.270 | AlteredExpression | disease | BEFREE | We demonstrated that plasma IL-17A levels has an accurate sensitivity and specificity to predict heart failure in serology-positive patients and might be a useful parameter to distinguish patients with or without cardiac impairment. | 28278264 | 2017 | ||||
|
0.270 | GeneticVariation | disease | BEFREE | Therefore, we investigated whether common polymorphisms of genes IL17A and IL17RA (coding interleukin 17 receptor A) contribute to genetic predisposition to heart failure and adverse clinical outcomes associated with it.A total of 1713 adult patients with congestive heart failure and 1713 age- and sex-matched controls were genotyped for promoter single nucleotide polymorphisms (SNPs), rs2275913 and rs8193037 in IL17A and rs4819554 in IL17RA, to assess the relationship between individual SNPs and the risk of congestive heart failure. | 27399111 | 2016 | ||||
|
0.270 | Biomarker | disease | BEFREE | NT-proBNP and IL-17 may play essential roles in the process of heart failure. | 27323026 | 2016 | ||||
|
0.270 | Biomarker | disease | RGD | The study of ISO induced heart failure rat model. | 19909738 | 2010 | ||||
|
0.270 | Biomarker | disease | RGD | H&E and Masson staining revealed that blockade of IL-17 can improve myocardial fibrosis in HF. | 19527710 | 2009 |