Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 Biomarker disease RGD Protective effect of oxymatrine on chronic rat heart failure. 21691940 2011
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 AlteredExpression disease BEFREE During end-stage human heart failure, we have demonstrated that type 1 IP3R (IP3R1) mRNA and protein levels are up-regulated, in contrast to other cardiac calcium regulatory proteins, such as the type 2 ryanodine receptor (RYR2) and type IIa sarcoplasmic reticulum calcium adenosine triphosphatase (SERCA2), which are down-regulated. 9476544 1997
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 AlteredExpression disease BEFREE Therapeutic upregulation of SERCA2 expression using replication deficient adenoviral expression vectors, pharmacological interventions using thyroid hormone analogues, beta-adrenergic receptor antagonists, and novel metabolically active compounds are currently under investigation for the treatment of uncompensated cardiac hypertrophy and heart failure. 16902596 2006
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 Biomarker disease BEFREE Our findings show a crucial role of LRP1/Pyk2/HIF-1α in hypoxia-induced cardiomyocyte SERCA2 downregulation, a pathophysiological process closely associated with heart failure. 25968337 2015
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 AlteredExpression disease BEFREE Our results highlight the interaction of Yulink with PPARγ in regulating Serca2 expression and suggest a mechanistic role of the Yulink in the development of human heart failure and SCD.-Tsai, C.-T., Kuo, M.-W., Lin, J.-L., Yu, A. L., Yu, J. 29401584 2018
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 AlteredExpression disease BEFREE Phospholamban (PLB) inhibits SERCA2 activity and is therefore a potential target to improve the cardiac performance in heart failure. 10468529 1999
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 Biomarker disease BEFREE In this review we describe the drugs adopted in clinical practice that activate SERCA2a/b function as well as new promising therapeutic tools using SERCA2 viral gene delivery to improve cardiac function and treat heart failure. 24361307 2014
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 AlteredExpression disease BEFREE A reduced activity and expression of SERCA2 protein have been described in heart failure and diabetic cardiomyopathy, resulting in an altered Ca(2+) handling and cardiac contractility. 25270119 2014
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 AlteredExpression disease BEFREE This finding led us to explore the expression of the presently known cardiac Ca2+-ATPase isoforms in heart failure. 16402920 2006
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 GeneticVariation disease BEFREE The observation that ATP2A2 rs1860561 gene variant associated with lower risk of life-threatening arrhythmia in HF patients suggests that selected calcium gene variants may modify the risk of SD even within the complex and polygenic pathological condition of HF. 24048583 2013
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 Biomarker disease BEFREE Strikingly, these mice show a rapid decrease in cardiac contractility and a rapid loss of SERCA2 protein, which is also seen in heart failure. 30575439 2019
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 AlteredExpression disease BEFREE These data also show that the altered SR function in human heart failure cannot be explained by altered protein levels of PLB and SERCA2. 8689655 1996
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 GeneticVariation disease BEFREE These data reveal myofibrillar Ca(2+)-sensitivity to be an important determinant of the cardiac effects of SERCA2 haploinsufficiency and raise the possibility that Darier disease patients are more susceptible to heart failure under certain conditions. 26064889 2015
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 Biomarker disease CTD_human Differential contractile impairment of fast- and slow-twitch skeletal muscles in a rat model of doxorubicin-induced congestive heart failure. 19776660 2009
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 AlteredExpression disease BEFREE The activation of IL6, IL6R and gp130 messenger ribonucleic acid (mRNA) and protein was studied via reverse transcription-polymerase chain reaction (RT-PCR) and immunohistology in donor hearts (n = 6) and compared with patients undergoing evaluation of ventricular arrhythmias (control, n = 9) or with advanced heart failure (n = 20). 11985915 2002
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Here, we examined the effect of EET-A, an orally active EET analog, and <i>c</i>-AUCB, an inhibitor of the EETs degrading enzyme soluble epoxide hydrolase, on the progression of post-myocardial infarction (MI) heart failure (HF) in normotensive Hannover Sprague-Dawley (HanSD) and in heterozygous <i>Ren-2</i> transgenic rats (TGR) with angiotensin II-dependent hypertension. 30881303 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker disease BEFREE Decreased anabolism because of alterations in the insulin-like growth factor 1 (IGF-1)/growth hormone (GH) axis and increased catabolism induced by proinflammatory cytokines like tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) have been reported to contribute to muscle wasting in chronic heart failure (CHF). 28695463 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease BEFREE After further adjustment for biomarkers (high-sensitivity C-reactive protein, lipoprotein-associated phospholipase A<sub>2</sub> activity, high-sensitivity troponin I, and B-type natriuretic peptide), IL-6 remained significantly associated with the risk of major adverse cardiovascular events (adj HR Q4:Q1 1.43, 95% CI 1.09-1.88) and cardiovascular death or heart failure (adj HR 1.79, 95% CI 1.22-2.63). 29066436 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE Chronic treatment of hypertension or heart failure very often includes an angiotensin-converting enzyme inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs) as renin-angiotensin system inhibitors (RASi) treatments. 30836981 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE We report on the availability of cardiac diagnostic technologies and select medications for heart failure (β-blockers, ACE inhibitors and furosemide). 28490619 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE NADPH oxidase-derived superoxide mediates angiotensin II (Ang II)-enhanced carotid body (CB) chemoreceptor sensitivity in CHF rabbits, and tempol, the superoxide dismutase (SOD) mimetic, inhibits this Ang II- and CHF-enhanced superoxide anion effect. 19091790 2009
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
0.600 Biomarker disease BEFREE More consistent to mammalians, adult zebrafish developed significant heart failure in concert with β1-AR downregulation, and GRK2 and brain natriuretic peptide (BNP) upregulation in response to prolonged, 14d ISO-stimulation. 28554511 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 AlteredExpression disease BEFREE Insulin insensitivity and adipokine abnormalities (the hallmarks of type 2 diabetes mellitus) are characteristic features of heart failure; conversely, neurohormonal systems activated in heart failure (norepinephrine, angiotensin II, aldosterone, and neprilysin) impair insulin sensitivity and contribute to microvascular disease in diabetes mellitus. 29038209 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE In patients with ischemic CHF the differences in CPX findings were statistically not significant in ACE D/D, I/D and I/I genotypes (peak oxygen consumptions 13.7 +/- 4.6; 14.6 +/- 5.1 and 14.5 +/- 5.0 ml/kg/min, respectively (p >0.05). 12911874 2003