Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression disease BEFREE The results were independent of the etiology of the heart failure and suggest that increased levels of atrial AT1R mRNA may occur in response to elevated atrial pressures in heart failure. 9281460 1997
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression disease BEFREE It may underlie the decrease in AT1 protein expression in human heart failure. 9302352 1997
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression disease BEFREE In human ventricles (n=13), message levels of atrial natriuretic peptide and AT(1) receptor were inversely correlated, which suggests a decrease in AT(1) receptor expression with progressive heart failure. 10715259 2000
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 GeneticVariation disease BEFREE Angiotensin-II type 1 receptor gene polymorphism and long-term survival in patients with idiopathic congestive heart failure. 10937949 1999
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease BEFREE In conclusion, the diminished angiotensin II vasoconstriction with age in heart failure patients is most likely due to a lower density of AT(1) receptors and may result from a longer period of exposure to heart failure in older patients. 15569271 2004
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 GeneticVariation disease BEFREE Here we demonstrate that a polymorphism in the AT1R gene (A1166C), linked to increased receptor activity, is associated with elevated levels of oxidative stress markers in heart failure patients but not in healthy controls. 16651460 2006
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease CTD_human Blockade of angiotensin II type 1 receptor (AT1) signaling attenuates heart failure following myocardial infarction (MI), perhaps through reduction of fibrosis in the noninfarcted myocardium. 17208988 2007
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease CTD_human Comparison of the cardioprotective effects of cardos and losartan in rats with experimental chronic cardiac insufficiency. 18214293 2007
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease CTD_human Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone. 18586661 2008
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 GeneticVariation disease BEFREE The results of this proof-of concept study provide the first evidence that the AGTR1 A1166C polymorphism could influence the response to candesartan in patients with heart failure who are receiving ACE inhibitors. 18594050 2008
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 GeneticVariation disease BEFREE We genotyped 134 patients with HF and reduced systolic function for the AT1R A1166C genotype using polymerase chain reaction and restriction fragment length polymorphism. 18612202 2009
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease BEFREE Heart failure-related genes, such as brain natriuretic peptide, connective tissue growth factor and osteopontin; calcium signaling-related genes, such as ryanodine receptor 2, sarcoendoplasmic reticulum Ca(2+)-ATPase 2A2 and adenylate cyclase 7; renin-angiotensin system-related genes, such as angiotensinogen, angiotensin II receptor, type 1 and type 2; and mitochondria-related genes, such as peroxisome proliferator-activated receptor-gamma co-activator-1alpha, cytochrome c and transcription factor A mitochondrial, were significantly changed at the apical ventricle rather than at the basal ventricle. 19300450 2009
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression disease BEFREE Because the increase in AT(1)R expression and transcription factor activation can be blocked by the AT(1)R antagonist losartan, a positive feedback mechanism of AT(1)R expression in CHF is suggested. 19717736 2009
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Therapeutic disease RGD The protective effects of telmisartan and losartan in ADR-induced heart failure may be partially due to regulation of circulating Ang-(1-7) and myocardial AT(1)R expression. 21963897 2011
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression disease BEFREE An upregulation in angiotensin II type 1 receptor expression was detected in medullary nuclei in WT CHF mice, which was significantly attenuated in SA mice with CHF. 22025374 2011
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 GeneticVariation disease BEFREE Our study suggests that the AT1R-1166CC genotype is associated with increased ICD therapies in patients with chronic HF, and the level of circulating miR-155 may be a potential marker for arrhythmic risk. 22939041 2012
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease BEFREE These data suggest that the serum levels of ghrelin are significantly positively correlated with Ang II in CHF patients and that ghrelin can inhibit Ang II-induced cardiomyocyte apoptosis by down-regulating AT1R, thereby playing a role in preventing HF. 24465706 2014
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 GeneticVariation disease BEFREE Endothelial dysfunction was present in CHF group and the presence of ecNOS a allele and AT1R C allele further impaired EDD. 24992619 2014
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 GeneticVariation disease BEFREE In conclusion, this meta-analysis suggests that the A1166C polymorphism in AT1R may not be associated with susceptibility to HF. 26345849 2015
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression disease BEFREE PVN expression of AT1R, HoxD10, and miR-7b was increased, whereas GABBR1 was lower in CHF. 26699387 2016
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease BEFREE In addition, the pharmacology of a new class of compounds which display both AT1-receptor blocking properties combined with inhibition of neprilysin, the vasopeptidase enzyme degradating natriuretic peptide (ARNi), will be reviewed, alongside with their impact in the pathophysiology of chronic HF. 27075034 2017
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease BEFREE AT1 receptor blocker azilsartan medoxomil normalizes plasma miR-146a and miR-342-3p in a murine heart failure model. 27321284 2017
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression disease BEFREE Intracellular Ang-II and nuclear AT1R protein levels were significantly increased in a heart failure model in which atrial fibrosis underlies atrial fibrillation. 28381466 2017
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression disease BEFREE Mas and AT1 receptor protein expressions, Ang-(1-7) and Ang II levels in CHF increased. 28848201 2017
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease BEFREE Sacubitril/valsartan (LCZ-696) is a combined neprilysin inhibitor and angiotensin AT1 receptor blocker approved in recent years for the treatment of chronic heart failure with reduced ejection fraction. 29286056 2017