Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease BEFREE There is an ANG II/AT1R/HoxD10/miR-7b/GABBR1 pathway in the PVN that contributes to sympathoexcitation and deterioration of cardiac function in CHF. 26699387 2016
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease BEFREE These data suggest that the serum levels of ghrelin are significantly positively correlated with Ang II in CHF patients and that ghrelin can inhibit Ang II-induced cardiomyocyte apoptosis by down-regulating AT1R, thereby playing a role in preventing HF. 24465706 2014
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 GeneticVariation disease BEFREE Our study suggests that the AT1R-1166CC genotype is associated with increased ICD therapies in patients with chronic HF, and the level of circulating miR-155 may be a potential marker for arrhythmic risk. 22939041 2013
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Therapeutic disease RGD To investigate the possible effects of telmisartan and losartan on cardiac function in adriamycin (ADR)-induced heart failure in rats, and to explore the changes in plasma level of angiotensin-(1-7)[Ang-(1-7)] and myocardial expression of angiotensin II type 1/2 receptors (AT(1)R / AT(2)R) and Mas receptor caused by the two drugs. 21963897 2012
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Therapeutic disease RGD Regulation of angiotensin-(1-7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure. 21963897 2012
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression disease BEFREE An upregulation in angiotensin II type 1 receptor expression was detected in medullary nuclei in WT CHF mice, which was significantly attenuated in SA mice with CHF. 22025374 2012
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Therapeutic disease RGD The protective effects of telmisartan and losartan in ADR-induced heart failure may be partially due to regulation of circulating Ang-(1-7) and myocardial AT(1)R expression. 21963897 2012
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease CTD_human Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone. 18586661 2011
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression disease BEFREE These data strongly suggest that multiple central and peripheral influences dynamically alter AT(1)R expression in CHF. 19717736 2009
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease BEFREE Heart failure-related genes, such as brain natriuretic peptide, connective tissue growth factor and osteopontin; calcium signaling-related genes, such as ryanodine receptor 2, sarcoendoplasmic reticulum Ca(2+)-ATPase 2A2 and adenylate cyclase 7; renin-angiotensin system-related genes, such as angiotensinogen, angiotensin II receptor, type 1 and type 2; and mitochondria-related genes, such as peroxisome proliferator-activated receptor-gamma co-activator-1alpha, cytochrome c and transcription factor A mitochondrial, were significantly changed at the apical ventricle rather than at the basal ventricle. 19300450 2009
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease CTD_human Comparison of the cardioprotective effects of cardos and losartan in rats with experimental chronic cardiac insufficiency. 18214293 2008
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease CTD_human Blockade of angiotensin II type 1 receptor (AT1) signaling attenuates heart failure following myocardial infarction (MI), perhaps through reduction of fibrosis in the noninfarcted myocardium. 17208988 2007
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 GeneticVariation disease BEFREE Here we demonstrate that a polymorphism in the AT1R gene (A1166C), linked to increased receptor activity, is associated with elevated levels of oxidative stress markers in heart failure patients but not in healthy controls. 16651460 2006
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease BEFREE In conclusion, the diminished angiotensin II vasoconstriction with age in heart failure patients is most likely due to a lower density of AT(1) receptors and may result from a longer period of exposure to heart failure in older patients. 15569271 2005
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease BEFREE An 89-year-old man with severe hypertension (190/82 mm Hg) and chronic heart failure (New York Heart Association class II) despite treatment with benidipine, doxazosin mesylate (INN, doxazosin), and furosemide was given oral candesartan cilexetil (4 mg/d), an angiotensin II type 1 receptor blocker metabolized via cytochrome p450 (CYP) 2C9. 14586391 2003
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression disease BEFREE In human ventricles (n=13), message levels of atrial natriuretic peptide and AT(1) receptor were inversely correlated, which suggests a decrease in AT(1) receptor expression with progressive heart failure. 10715259 2000
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 GeneticVariation disease BEFREE Angiotensin-II type 1 receptor gene polymorphism and long-term survival in patients with idiopathic congestive heart failure. 10937949 2000
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression disease BEFREE The goals of our study were the development of a quantitative polymerase chain reaction for angiotensin II receptor type 1 mRNA to determine the angiotensin receptor type 1 (AT1) mRNA content in the atria of patients with end-stage heart failure. 8872858 1997
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression disease BEFREE Angiotensin II receptor type 1 mRNA is upregulated in atria of patients with end-stage heart failure. 9281460 1997
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression disease BEFREE It may underlie the decrease in AT1 protein expression in human heart failure. 9302352 1997