| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | disease | BEFREE | Therefore, we aimed to investigate whether Six1 and PRC2 are indeed involved in the regulation of the miR-25 level in the setting of heart failure. | 30771307 | 2019 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Multiple logistic regression analysis showed PBMC miR-221, miR-19b-5p, miR-25-5p, and hypertension to be the independent predictive factors for HF in CHD patients. | 30088484 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Our data indicate that miR-25 TuD is an effective long-term suppressor of miR-25 and a promising therapeutic candidate to treat heart failure. | 29273502 | 2018 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Interestingly, we discovered miR-25 expression in humans is initially decreased at the onset of heart failure but is later increased in end-stage heart failure. | 29499204 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Moreover, the SERCA2A and LVEF were reduced, while the miR-25 was improved in the HF + CCM + miR-25 group compared to the HF + CCM group. | 30069393 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | (2014) show that upregulation of microRNA-25 impairs calcium handling leading to pump dysfunction and that targeting microRNA-25 using antisense oligonucleotides reverses pump dysfunction and improves survival in mice with heart failure. | 24896535 | 2014 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | These data reveal that increased expression of endogenous miR-25 contributes to declining cardiac function during heart failure and suggest that it might be targeted therapeutically to restore function. | 24670661 | 2014 | ||||
|
0.080 | Biomarker | disease | BEFREE | Furthermore, in vivo inhibition of miR-25 by a specific antagomir evoked spontaneous cardiac dysfunction and sensitized the murine myocardium to heart failure in a Hand2-dependent manner. | 24161931 | 2013 |