Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.350 | Biomarker | disease | BEFREE | High serum TNF-α concentrations may contribute to the association between NAFLD and IR, while increased hepatic triglycerides appear to be a determinant of the development of HIOL in non-diabetic subjects without haemochromatosis. | 30660761 | 2019 | ||||
|
0.350 | GeneticVariation | disease | BEFREE | Tumor necrosis factor-alpha promoter variants and iron phenotypes in 785 hemochromatosis and iron overload screening (HEIRS) study participants. | 20178892 | 2010 | ||||
|
0.350 | Biomarker | disease | CTD_human | TNF-alpha -308G>A allelic variant modulates iron accumulation in patients with hereditary (homozygous C282Y) hemochromatosis, but the effect of the TNF-alpha -308A allele on clinical manifestations of hemochromatosis was less accentuated than expected from the increased iron load associated with this allele. | 16793930 | 2006 | ||||
|
0.350 | GeneticVariation | disease | BEFREE | TNF-alpha -308G>A allelic variant modulates iron accumulation in patients with hereditary (homozygous C282Y) hemochromatosis, but the effect of the TNF-alpha -308A allele on clinical manifestations of hemochromatosis was less accentuated than expected from the increased iron load associated with this allele. | 16793930 | 2006 | ||||
|
0.350 | AlteredExpression | disease | BEFREE | Tumour necrosis factor alpha and its promoter polymorphisms' role in the phenotypic expression of hemochromatosis. | 12940442 | 2003 | ||||
|
0.350 | AlteredExpression | disease | BEFREE | Mean concentrations of immunoreactive TNF-alpha in supernatants were significantly lower for subjects with hereditary hemochromatosis as compared to healthy controls (P less than .037) and patients with iron-loading anemia (P less than .005); differences between homozygotes for hemochromatosis and healthy controls were up to 4.5-fold at 4 hours (P = .008), 1.9-fold at 12 hours (P = .036), and 7.0-fold at 36 hours (P = .001). | 1558977 | 1992 |