| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | group | BEFREE | With the aim of determining the role of KLF1 gene variations in HbF induction and their genotype phenotype relationship, in this study, we screened 370 individuals with different hemoglobinopathy condition. | 30529538 | 2019 | ||||
|
0.080 | GeneticVariation | group | BEFREE | This study aimed to investigate whether KLF1 mutation can associate with high level of HbF in individuals with increased fetal hemoglobin referred for screening of hemoglobinopathies in south of Iran. | 29420372 | 2018 | ||||
|
0.080 | GeneticVariation | group | BEFREE | Here we report a novel KLF1 gene variation codon 211 A→G (c.632 A>G) in a family who was referred for hemoglobinopathy screening. | 28369821 | 2017 | ||||
|
0.080 | GeneticVariation | group | BEFREE | Mutations in the gene encoding EKLF may cause hemoglobinopathies, such as hereditary persistence of fetal hemoglobin and β-thalassemia intermedia, and congenital dyserythropoietic anemia type IV, which is a hematopoietic disorder. | 27708211 | 2016 | ||||
|
0.080 | AlteredExpression | group | BEFREE | KLF1 is therefore an important genetic factor associated with increased Hb F and in combination with other modifying factors could explain the phenotypic variation of Hb F expression in this common hemoglobinopathy. | 27282573 | 2016 | ||||
|
0.080 | GeneticVariation | group | BEFREE | KLF1 mutations are important in a screening program for hemoglobinopathies. | 26794457 | 2016 | ||||
|
0.080 | GeneticVariation | group | BEFREE | This supports the emerging concept that monoallelic KLF1 mutations can play a modulatory role in hemoglobinopathies. | 25082863 | 2014 | ||||
|
0.080 | Biomarker | group | BEFREE | These results suggest that strategies designed to antagonize EKLF function in adults with hemoglobinopathy, in an attempt to reactivate gamma-globin gene expression, may adversely affect other essential aspects of red blood cell physiology.(Blood.2000;95:1827-1833) | 10688844 | 2000 |