Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.030 | Biomarker | disease | BEFREE | Additionally, long-term exposure of MC-LR at low concentration remarkably promoted the expression of NF-κB p65, COX-2, iNOS, TNF-α, IL-1β, and IL-6 in the cells, suggesting that long-term MC-LR exposure at low concentration can induce inflammatory reaction to HepG2 cells, which might account for MC-induced human hepatitis. | 29117589 | 2018 | ||||
|
0.030 | Biomarker | disease | BEFREE | The mean serum IL-6 concentration was significantly higher in AC (mean ± SD:21.52 ± 15.01 pg/mL), NAC (20.07 ± 32.12 pg/mL) and HT (15.14 ± 17.18 pg/mL) when compared to the control group (C) (1.67 ± 0.42 pg/mL) (Mann-Whitney U test: p < .001 for all comparisons). | 29272979 | 2018 | ||||
|
0.030 | AlteredExpression | disease | BEFREE | Besides, the IL-6 levels significantly increased with cirrhosis development, as compared to carriers and hepatitis subjects. | 24841049 | 2015 |