Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3455
Gene Symbol: IFNAR2
IFNAR2
0.340 Biomarker disease CTD_human
Entrez Id: 3588
Gene Symbol: IL10RB
IL10RB
0.330 Biomarker disease CTD_human
Entrez Id: 3459
Gene Symbol: IFNGR1
IFNGR1
0.320 Biomarker disease CTD_human
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE The purpose of this study was to evaluate the relationship of p53 gene mutation to high or low levels of aflatoxin in the diet and to HBV infection. 1279184 1992
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 Biomarker disease BEFREE Furthermore, it is possible that the proliferation of these oval-type cells may partly account for the elevation of serum alpha-fetoprotein frequently seen in precancerous stages of hepatitis B virus-associated human hepatocellular carcinoma. 1280243 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Because this is the fourth case reported in which hepatitis B virus-associated rearrangements have affected chromosome 17, it is conceivable that a loss of important cellular genes (such as the p53 antioncogene on chromosome 17) may be a crucial step in hepatitis B virus-related hepatocarcinogenesis. 1312986 1992
Entrez Id: 890
Gene Symbol: CCNA2
CCNA2
0.040 GeneticVariation disease BEFREE Thus, HBV DNA integration in the cyclin A gene resulted in a strong expression of hybrid HBV-cyclin A transcripts encoding a stabilized cyclin A. 1321406 1992
Entrez Id: 7039
Gene Symbol: TGFA
TGFA
0.050 AlteredExpression disease BEFREE These findings show that the presence of HBV DNA appears to cause a significant up-regulation of the TGF-alpha gene. 1328501 1992
Entrez Id: 9213
Gene Symbol: XPR1
XPR1
0.030 Biomarker disease BEFREE Retinoid X receptor RXR alpha binds to and trans-activates the hepatitis B virus enhancer. 1329088 1992
Entrez Id: 6667
Gene Symbol: SP1
SP1
0.010 Biomarker disease BEFREE Regulation of transcription from the hepatitis B virus major surface antigen promoter by the Sp1 transcription factor. 1331502 1992
Entrez Id: 110006328
Gene Symbol: ERVK-32
ERVK-32
0.100 Biomarker disease BEFREE Cells transfected with human interleukin 6 cDNA acquire binding sites for the hepatitis B virus envelope protein. 1334115 1992
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker disease BEFREE Cells transfected with human interleukin 6 cDNA acquire binding sites for the hepatitis B virus envelope protein. 1334115 1992
Entrez Id: 64006
Gene Symbol: ERVK-6
ERVK-6
0.100 Biomarker disease BEFREE Cells transfected with human interleukin 6 cDNA acquire binding sites for the hepatitis B virus envelope protein. 1334115 1992
Entrez Id: 100862688
Gene Symbol: ERVK-11
ERVK-11
0.030 Biomarker disease BEFREE Earlier studies revealed that human interleukin 6 (IL-6) contains recognition sites for the hepatitis B virus (HBV) envelope (env) protein, and that IL-6 and anti-IL-6 antibodies, respectively, inhibited the interaction of cells expressing a receptor for HBV with the preS(21-47) segment of the HBV env protein, encompassing the complementary attachment site for IL-6. 1334115 1992
Entrez Id: 100616100
Gene Symbol: ERVK-2
ERVK-2
0.010 Biomarker disease BEFREE Earlier studies revealed that human interleukin 6 (IL-6) contains recognition sites for the hepatitis B virus (HBV) envelope (env) protein, and that IL-6 and anti-IL-6 antibodies, respectively, inhibited the interaction of cells expressing a receptor for HBV with the preS(21-47) segment of the HBV env protein, encompassing the complementary attachment site for IL-6. 1334115 1992
Entrez Id: 100616442
Gene Symbol: ERVK-12
ERVK-12
0.010 Biomarker disease BEFREE Earlier studies revealed that human interleukin 6 (IL-6) contains recognition sites for the hepatitis B virus (HBV) envelope (env) protein, and that IL-6 and anti-IL-6 antibodies, respectively, inhibited the interaction of cells expressing a receptor for HBV with the preS(21-47) segment of the HBV env protein, encompassing the complementary attachment site for IL-6. 1334115 1992
Entrez Id: 100616445
Gene Symbol: ERVK-22
ERVK-22
0.010 Biomarker disease BEFREE Earlier studies revealed that human interleukin 6 (IL-6) contains recognition sites for the hepatitis B virus (HBV) envelope (env) protein, and that IL-6 and anti-IL-6 antibodies, respectively, inhibited the interaction of cells expressing a receptor for HBV with the preS(21-47) segment of the HBV env protein, encompassing the complementary attachment site for IL-6. 1334115 1992
Entrez Id: 3131
Gene Symbol: HLF
HLF
0.010 Biomarker disease BEFREE The expression of nine oncogenes (c-myc, N-myc, N-ras, H-ras, k-ras, abl, fos, src, and raf) and two tumor suppressor genes (p53 and RB) were studied by northern blot hybridization in six human hepatocellular carcinoma or hepatoblastoma cell lines (PLC/PRF/5, Hep3B, Hep G2, 2.2.15, HLE, and HLF) and in a human embryonic lung fibroblast cell line (WI-38) to look for differences that might be associated with the presence (PLC/PRF/5, Hep3B, and 2.2.15) or absence (Hep G2, HLE, and HLF) of integrated hepatitis B virus (HBV) DNA. 1335479 1992
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.010 Biomarker disease BEFREE The expression of nine oncogenes (c-myc, N-myc, N-ras, H-ras, k-ras, abl, fos, src, and raf) and two tumor suppressor genes (p53 and RB) were studied by northern blot hybridization in six human hepatocellular carcinoma or hepatoblastoma cell lines (PLC/PRF/5, Hep3B, Hep G2, 2.2.15, HLE, and HLF) and in a human embryonic lung fibroblast cell line (WI-38) to look for differences that might be associated with the presence (PLC/PRF/5, Hep3B, and 2.2.15) or absence (Hep G2, HLE, and HLF) of integrated hepatitis B virus (HBV) DNA. 1335479 1992
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.030 AlteredExpression disease BEFREE In addition, expression of ICAM-1 by hepatitis B virus-DNA transfected HepG2 cells suggests other, still unknown, triggering mechanisms in the induction of such adhesion molecules, for instance gene activation by viral genome, or autocrine virus-induced hepatocellular cytokine production. 1346374 1992
Entrez Id: 2875
Gene Symbol: GPT
GPT
0.100 Biomarker disease BEFREE The mean of alanine aminotransferase values was similar in patients with or without hepatitis B virus DNA in serum by polymerase chain reaction. 1383416 1992
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 AlteredExpression disease BEFREE Following mitogen exposure HBV DNA levels increased above pre-stimulation levels in 19/25 PHA cultures, 6/15 ConA cultures, 1/15 LPS cultures, and 1/15 IL2 cultures. 1402824 1992
Entrez Id: 7448
Gene Symbol: VTN
VTN
0.100 GeneticVariation disease BEFREE DNA sequence analysis of both primate and patient liver hepatitis B virus confirmed the presence of the DNA encoding the S protein variant and associates this DNA with the predominant hepatotropic virus in liver infection. 1568715 1992
Entrez Id: 1041
Gene Symbol: CDSN
CDSN
0.100 GeneticVariation disease BEFREE DNA sequence analysis of both primate and patient liver hepatitis B virus confirmed the presence of the DNA encoding the S protein variant and associates this DNA with the predominant hepatotropic virus in liver infection. 1568715 1992
Entrez Id: 56955
Gene Symbol: MEPE
MEPE
0.010 Biomarker disease BEFREE Forty of the positive children were HBeAg- and six anti-HBe-positive; two were negative for both.Of 45 36 had HBV DNA in serum. 1593366 1992