|
HLA-DPA1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Assessment of HLADP gene rs3128917 and rs9380343 polymorphisms in chronic HBV infection.
|
31290749 |
2019 |
|
HLA-DPA1
|
0.200 |
Biomarker
|
disease |
BEFREE |
HLA-DPA1*01:03:01 was correlated with lower ORs of undetectable anti-HBs titers, while -DPA1*02:02:02 and -DPB1*05:01:01 were correlated with higher ORs.
|
31515149 |
2019 |
|
HLA-DPA1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrated, for the first time, that expression of HLA-DPA1 alleles and rs3077 affected the risk of HBV infection.
|
30267609 |
2019 |
|
HLA-DPA1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Viral and host predictors of relapse were evaluated, including hepatitis B virus (HBV) surface antigen (HBsAg) level, anti-HBV core antibody level, and presence of single-nucleotide polymorphisms in the genes encoding the receptors NTCP (rs2296651) and CTLA4 (rs231775) and in the 3' untranslated regions of the genes encoding HLA-DPA1 (rs3077) and HLA-DPB1 (rs9277535); posttherapy predictors of relapse were also investigated.
|
29300980 |
2018 |
|
HLA-DPA1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The HLA-DPA1 rs3077 variant was associated with a protective effect increasing the spontaneously resolved HBV infection (OR 0.64, 95% CI 0.41-0.98, P=0.039, dominant genetic model).
|
27051043 |
2016 |
|
HLA-DPA1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Japanese patients (202) who were hepatitis B e antigen positive at baseline, received LAM as first-line treatment, and consented to HLA-DP genotyping (HLA-DPA1 rs3077 and HLA-DPB1 rs9277535) were categorized into two cohorts, viz., a cohort who achieved virological response without rescue therapy (cohort 1) and those who did so with rescue therapy (cohort 2).
|
25103089 |
2015 |
|
HLA-DPA1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We performed trans-ethnic association analyses of HLA-DPA1, HLA-DPB1 alleles and haplotypes with hepatitis B virus infection and disease progression among Asian populations comprising Japanese, Korean, Hong Kong, and Thai subjects.
|
24520320 |
2014 |
|
HLA-DPA1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We compared the SNPs in the HLA-DPA1 gene (rs3077) and the IFN-γ receptor-2 gene (rs2284553 and rs9808753) of 100 treatment-naive hepatitis B e antigen (HBeAg)-negative CHB patients with undetectable HBV DNA with 100 age- and sex-matched controls with HBV DNA > 2000 IU/mL.
|
23980639 |
2014 |
|
HLA-DPA1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We genotyped SNPs rs3077 (near HLA-DPA1) and rs9277378 and rs3128917 (both near HLA-DPB1) in 500 HBV carriers (hepatitis B surface antigen [HBsAg]-positive), 245 non-HBV infected controls (HBsAg- and antibody to hepatitis B core protein [anti-HBc]-negative), and 259 subjects with natural HBV clearance (HBsAg-negative, anti-HBc-positive).
|
23825586 |
2013 |
|
HLA-DPA1
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
New loci associated with chronic hepatitis B virus infection in Han Chinese.
|
24162738 |
2013 |
|
HLA-DPA1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Two single nucleotide polymorphisms (SNP), rs3077 near HLA-DPA1 region and rs9277535 near HLA-DPB1 region, have been shown to be associated with HBV persistence after acute HBV infection.
|
23326374 |
2013 |
|
HLA-DPA1
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
|
23760081 |
2013 |
|
HLA-DPA1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Examination of large numbers of cohorts revealed that several SNPs in both HLA-DPA1 and HLA-DPB1 loci are associated with persistent HBV infection in Asian populations.
|
24023482 |
2013 |
|
HLA-DPA1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A highly significant association of HLA-DPA1 rs3077 with HBV infection was observed in Caucasians.
|
22448225 |
2012 |
|
HLA-DPA1
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.
|
22737229 |
2012 |
|
HLA-DPA1
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.
|
22737229 |
2012 |
|
HLA-DPA1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
By using logistic regression analysis, these two SNPs in the HLA-DPA1 and HLA-DPB1 genes were significantly associated with HBV infection in Han Chinese populations (P = 0.021∼3.36×10(-8) at rs2395309; P = 8.37×10(-3)∼2.68×10(-10) at rs9277535).
|
21904616 |
2011 |
|
HLA-DPA1
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.
|
21750111 |
2011 |
|
HLA-DPA1
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.
|
21750111 |
2011 |
|
HLA-DPA1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
HLA - DPA1 rs3077 T was strongly associated with decreased risk of chronic HBV infection (odds ratio, .62; P = .001), consistent with the previous report.
|
21402545 |
2011 |
|
HLA-DPA1
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.
|
19349983 |
2009 |