| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | In the present study, we identified a novel regulatory mechanism in which the L-HBs protein activates IL-8 via endoplasmic reticulum stress, suggesting a key role for IL-8 in the immune response to HBV and a potential new target for antiviral treatments of HBV infection. | 30240958 | 2018 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Enhanced levels of interleukin-8 are associated with hepatitis B virus infection and resistance to interferon-alpha therapy. | 25407531 | 2014 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | The IL-8 gene polymorphisms and the risk of the hepatitis B virus/infected patients. | 22335768 | 2012 | ||||
|
0.080 | Biomarker | disease | BEFREE | Compared to healthy controls (n = 20) and patients who resolved HBV infection, OHB-infected patients displayed an increase in interleukin (IL)-2 secretion in addition to a characteristic inflammation profile (decrease in IL-8 and tumour necrosis factor-alpha levels and increased levels of tumour growth factor-beta). | 22241125 | 2011 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Multiple regression analysis showed that the presence of T/A or A/A at IL-8 -251 may indicate higher potential risk of hepatitis B infection (AOR = 2.847; 95% CI: 1.083-8.656). | 21780129 | 2011 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | In addition, we also demonstrated that COX-2 expression activated by IL-8 was mediated through CREB and C/EBP, which maintains the inflammatory environment associated with HBV infection. | 21957142 | 2011 | ||||
|
0.080 | Biomarker | disease | BEFREE | We further discovered that miR-520b directly targets the 3'-untranslated region (3'UTR) of either hepatitis B X-interacting protein (HBXIP) or interleukin-8 (IL-8), which has been reported to contribute to cell migration. | 21343296 | 2011 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | The interleukin-8 promoter is transcriptionally activated by interleukin-1, tumor necrosis factor alpha, phorbol myristate acetate, or hepatitis B virus X protein through a sequence located between positions -91 and -71. | 8413306 | 1993 |