TaqMan SNP genotyping was employed to determine the alleles and genotypes of MTHFRC677T in 2511 subjects from various stages of HBV infection and 549 healthy controls.
In the data classified by age and etiology, MTRR 66A>G over the age of 65 years, MTHFR 1298A>C under the age of 65 years and the MTRR 66AG+GG genotype in the hepatitis B virus (HBV) patients were increased risk factors for the disease.