Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease BEFREE We determined prevalence of chronic HCV infection in consecutive Alabama and Ontario referred adults with HFE p.C282Y homozygosity. 31056361 2020
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease BEFREE In the present study, we correlated different host single-nucleotide polymorphisms (SNPs) in the IL28B, CTLA4, LDLr, and HFE genes and mitochondrial DNA (mtDNA) haplogroups with the outcome of HCV infection and the response to pegylated-interferon plus ribavirin (pegIFN-RBV) treatment. 25296442 2014
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease BEFREE To investigate the association of progression of HCC with ghrelin and HFE gene polymorphisms in HCV Egyptian patients. 23845776 2013
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease BEFREE Hepatitis B virus (4% and 9%; P = 0.04) and hepatitis C virus (6% and 19%; P = 0.002) infections were more frequent in patients with non-HFE-related iron overload. 20101754 2010
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease BEFREE In contrast, livers with hepatitis C showed a similar frequency of HFE mutations as the general population: C282Y=15%, H63D=27%. 20208481 2010
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease LHGDN Porphyria cutanea tarda, hepatitis C, uroporphyrinogen decarboxylase and mutations of HFE gene. A case-control study. 19001803 2009
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease BEFREE Hemochromatosis gene (HFE) mutations and the hepatitis C virus (HCV) are known risk factors for porphyria cutanea tarda (PCT), but interactions with erythrocytic uroporphyrinogen decarboxylase (UROD) have seldom been addressed. 19001803 2009
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease BEFREE To determine the prevalence of the HFE gene mutations p.Cys282Tyr (C282Y), p.His63Asp (H63D) and p.Ser65Cys (S65C), the p.Tyr250X (Y250X) mutation of the TFR2 gene, and HCV infection in patients with PCT in the Czech population, and to make comparison of the iron status among the respective genotypes. 18565178 2008
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease BEFREE The prevalence of HFE C282Y gene mutation is increased in Spanish patients with porphyria cutanea tarda without hepatitis C virus infection. 17062032 2006
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease BEFREE The aim of this work was to assess the influence of HFE mutations and serum and hepatic measures of iron status on baseline features and response to lead-in therapy in subjects with advanced chronic hepatitis C enrolled in the Hepatitis C Anti-viral Long-term Treatment to prevent Cirrhosis (HALT-C) Trial. 17101320 2006
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease BEFREE The relationship of H63D HFE gene mutations with chronic hepatitis C and the possible influence of HCV infection on iron metabolism needs further analysis. 16273299 2005
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease BEFREE In all subjects, hepatitis B surface antigen (HBsAg), anti-HCV and HFE gene mutations were assayed; alcohol intake was recorded by history. 15894495 2005
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease BEFREE Additional tests for hepatitis C virus (HCV) and hemochromatosis gene mutations were carried out. 15761419 2005
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 Biomarker disease CTD_human Ribavirin in the treatment of hepatitis C. 15865084 2005
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease BEFREE Iron, the HFE gene, and hepatitis C. 15464655 2004
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease BEFREE Therefore our aim was to assess associations between HFE mutations and hepatic inflammation and stage of fibrosis in German hepatitis C patients. 15287851 2004
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease BEFREE The recent increasing contribution of hepatitis C virus infection to PCT in Japan has also been recognized. but there have been no PCT cases in Japan with HFE gene mutations. 15239394 2004
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 Biomarker disease BEFREE Furthermore, the presence of HCV infection was determined and related to the patients' HFE gene status. 15101996 2004
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease BEFREE Severe alterations of the HFE gene (42 patients, 28%), hepatitis C virus infection (33 patients, 22%), and dysmetabolic syndrome with iron overload (DSIO) (22 patients, 15%) emerged as the main causes, and other single causes were found in 20 patients (13%). 12601495 2003
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease BEFREE To investigate the relations between hemochromatosis gene (HFE) mutations and PCT in the south of France and their links with chronic hepatitis C virus (HCV) infection. 12673077 2003
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease BEFREE our results suggest that the C282Y mutation, but not the H63D mutation, of the HFE gene is frequently associated with stainable iron in the liver in HCV-related chronic hepatitis. 14972004 2003
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease BEFREE These results suggest that HFE mutations accelerate hepatic fibrosis in hepatitis C but may not be responsible for progression to end-stage liver disease. 12557137 2003
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease BEFREE In HCV-infected patients, heterozygosity for the C282Y mutation in HFE was significantly associated with elevated serum ferritin levels, stainable liver iron, and advanced fibrosis or cirrhosis (F2-F4). 14557859 2003
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 GeneticVariation disease BEFREE Screening for HFE mutations should be considered in HCV infection. 12586300 2003
Entrez Id: 3077
Gene Symbol: HFE
HFE
0.400 Biomarker disease BEFREE Serum markers of iron status and HFE mutations were determined in 179 patients with alcoholic cirrhosis and 98 patients with hepatitis B and/or hepatitis C virus-related cirrhosis. 12003382 2002