| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | disease | BEFREE | Interestingly, C9 is significantly reduced at the mRNA level in chronically HCV infected liver biopsy specimens, while many hepatocyte derived complement components (C6, C8, Factor B, MASP1, and MBL) and unrelated genes remain mostly unaffected. | 30593637 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Elevated serum activity of MBL and ficolin-2 as biomarkers for progression to hepatocellular carcinoma in chronic HCV infection. | 30798068 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | MBL-HCV1, a neutralizing human monoclonal antibody (mAb) targeting the HCV envelope, was combined with a licensed oral direct-acting antiviral (DAA) to prevent HCV recurrence post-transplant in an open-label exploratory efficacy trial. | 28127942 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | The ability of MBL-HCV1 to prevent HCV recurrence after liver transplantation was investigated in a phase 2 randomized clinical trial evaluating six MBL-HCV1-treated subjects and five placebo-treated subjects. | 24956119 | 2014 | ||||
|
0.080 | Biomarker | disease | BEFREE | MBL may play a role as disease modifier in HCV infection. | 19703233 | 2009 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | The odds ratio estimations were not significant, and the values obtained cannot suggest that the presence of allele variant MBL*B could have some influence in the risk of HCV infection progression to liver cirrhosis and that the presence of allele MBL*D could confer some protection against disease progression, but a larger sample size is necessary to confirm the present results. | 19540295 | 2009 | ||||
|
0.080 | Biomarker | disease | BEFREE | Our findings indicate that MBL might represent an important antiviral molecule having a protective role in the first stages of HCV infection, as shown by the increased frequency of wild-type alleles in control population as compared to the infected group. | 17513174 | 2007 | ||||
|
0.080 | Biomarker | disease | BEFREE | MBL may be one of the factors that influence the course of HCV infection. | 11063157 | 2000 |