| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | TCR sequencing was performed to analyse impact of HCV infection on Vδ2 T-cell repertoire. | 31074195 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Using a model for altered antigen recognition, we determined how TCR-pMHC affinity influenced the reactivity of hepatitis C virus (HCV) TCR gene-modified T-cells against a panel of naturally occurring HCV peptides and HCV-expressing tumor targets. | 28634816 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | TCR gene-modified T cells can efficiently treat established hepatitis C-associated hepatocellular carcinoma tumors. | 26842125 | 2016 | ||||
|
0.080 | Biomarker | disease | BEFREE | TCR repertoires used against two immunodominant HCV determinants--the highly polymorphic, HLA-B*0801 restricted (1395)HSKKKCDEL(1403) (HSK) and the comparatively conserved, HLA-A*0101-restricted, (1435)ATDALMTGY(1443) (ATD)--were analyzed in clearly defined cohorts of HLA-matched, HCV-infected individuals with persistent infection and HCV clearance. | 21160049 | 2011 | ||||
|
0.080 | Biomarker | disease | BEFREE | Tumor cell recognition by HCV TCR transduced CD8(-) Jurkat cells and CD4(+) PBL-derived T cells indicated this TCR was CD8-independent, a property consistent with other high affinity TCRs. | 20686664 | 2010 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | We demonstrate that a known in vivo HCV mutation involving a TCR contact residue significantly diminishes T cell recognition and, in contrast to the original sequence, fails to effectively prime naive T cells. | 18941234 | 2008 | ||||
|
0.080 | Biomarker | disease | BEFREE | We studied the T cell repertoires in sequential liver biopsy samples from five individuals with chronic HCV infection using TCR spectratype analysis; four subjects had been treated with IFN-alpha during the interval between biopsies. | 15802962 | 2005 | ||||
|
0.080 | Biomarker | disease | BEFREE | One of these TCR sequences was used by a cell line directed against a viral CTL epitope in an HCV-infected animal indicating the functionality of this V region in the context of immune defense against pathogens. | 12682248 | 2003 |