| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | GeneticVariation | disease | BEFREE | Importantly, we found that Vβ27, a member of CDR3 subfamily, might play an important role in the clearance of HCV. | 30591202 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | The representative results of TCR Vβ by CDR3 were also obtained from liver tissues and peripheral blood lymphocytes (PBL) of 21 chronically HCV-infected patients without MC. | 23574322 | 2013 | ||||
|
0.070 | Biomarker | disease | BEFREE | Greater clonal evolution of SR than CE memory B cells was revealed by analysis of phylogenetic trees and CDR3 lengths. | 21980500 | 2011 | ||||
|
0.070 | Biomarker | disease | BEFREE | Furthermore, the CDR3 sequences in some of our MCII patients were highly similar to those described in HCV-positive patients with non-Hodgkin's lymphoma (NHL). | 16475992 | 2006 | ||||
|
0.070 | Biomarker | disease | BEFREE | Amplification of CDR3 of the Ig heavy chain gene from DNA isolated from each EBV(+)/HCV(+) B-cell NHL indicated the presence of monoclonal B-cell expansion. | 15753988 | 2005 | ||||
|
0.070 | Biomarker | disease | BEFREE | These data indicate: 1) NMZL is derived from B cells that have experienced the germinal center reaction; 2) the preferential usage of a VH1-69 segment in the majority of the HCV-positive NMZL cases with similar CDR3s suggests the presence of a common antigen, probably a HCV antigen epitope, involved in the B-cell selection; and 3) the use of a VH4-34 segment suggests a role of yet unknown B-cell superantigen(s) in the selection of tumor B-cell precursors in HCV-negative NMZL. | 11438472 | 2001 | ||||
|
0.070 | Biomarker | disease | BEFREE | Moreover, because HCV is the recognized pathologic agent of MC and the CDR3 amino acid sequences of some HCV-associated NHLs also present a high homology for antibody specific for the E2 protein of HCV, it may be reasonable to speculate that HCV E2 protein is one of the chronic antigenic stimuli involved in the lymphomagenetic process. | 11071657 | 2000 |