APOBEC3G
|
0.100 |
Biomarker
|
group |
BEFREE |
ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.
|
31253590 |
2019 |
APOBEC3G
|
0.100 |
Biomarker
|
group |
BEFREE |
The antiviral function of these proteins was first discovered when research in the field of HIV infection revealed that one member of the family, namely APOBEC3G, restricts HIV infection in T lymphocytes and that the viral infectivity factor protein drives the proteosomal degradation of this enzyme, thus overriding its antiviral function.
|
29345375 |
2018 |
APOBEC3G
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The frequency of APOBEC3G -571CC and CC + GC genotypes were higher in early HIV disease stage as compared to healthy controls (23.9% vs. 12.8%, OR = 2.23, P = 0.08; 28.3% vs. 14.1%, OR = 2.40, P = 0.04).
|
29864532 |
2018 |
APOBEC3G
|
0.100 |
Biomarker
|
group |
BEFREE |
Apobec3G-Based Strategies to Defeat HIV Infection.
|
26957196 |
2016 |
APOBEC3G
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study a well-characterized panel of 49 individuals either infected with HIV-1 or uninfected was compiled and analyzed for the effect of HIV infection status, viral load, and antiretroviral treatment on specific gene expression. mRNA was extracted and reverse transcribed from purified CD4+ cells, and quantitative real-time PCR was utilized to scrutinize differences in the expression of four host genes that have been demonstrated to either stimulate (HSP90 and LEDGF/p75) or restrict (p21/WAF1 and APOBEC3G) proviral integration.
|
24482297 |
2014 |
APOBEC3G
|
0.100 |
Biomarker
|
group |
BEFREE |
APOBEC3G can counteract HIV infection in at least two ways: by inducing lethal mutations on the viral cDNA; and by blocking steps in reverse transcription and viral integration into the host genome.
|
23724012 |
2013 |
APOBEC3G
|
0.100 |
Biomarker
|
group |
BEFREE |
This body of work suggests that the role of A3G in HIV infection is more complex than heretofore appreciated and supports the hypothesis that HIV has evolved to exploit the action of this host factor.
|
22546055 |
2012 |
APOBEC3G
|
0.100 |
Biomarker
|
group |
BEFREE |
Multi-scale modeling of HIV infection in vitro and APOBEC3G-based anti-retroviral therapy.
|
22346743 |
2012 |
APOBEC3G
|
0.100 |
Biomarker
|
group |
BEFREE |
First, A3G was shown to be able to terminate HIV infection by deaminating the cytosine residues to uracil in the minus strand of the viral DNA during reverse transcription.
|
22301159 |
2012 |
APOBEC3G
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To our knowledge, this is the first study analyzing A3G/F expression in HIV-infected children, and it may pave the way to a better understanding of the host factors governing HIV disease in the pediatric setting.
|
21897871 |
2011 |
APOBEC3G
|
0.100 |
Biomarker
|
group |
BEFREE |
APOBEC3F (A3F) is a member of the family of cytidine deaminases that is often coexpressed with APOBEC3G (A3G) in cells susceptible to HIV infection.
|
20702622 |
2010 |
APOBEC3G
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, these results indicate that Nef7.A3G can effectively restrict HIV infection and replication by restoring the virion incorporation of A3G, even in the presence of Vif.
|
19324886 |
2009 |
APOBEC3G
|
0.100 |
Biomarker
|
group |
BEFREE |
Meta-analyses of large cohort studies have identified numerous 'AIDS restriction genes' that regulate HIV cell entry (particularly chemokine coreceptors and their ligands), acquired and innate immunity (major histocompatibility complex, killer cell immunoglobulin-like receptor, and cytokines), and others [tripartite interaction motif 5 alpha (TRIM5alpha) and apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G] that influence outcome of HIV infection.
|
19317737 |
2009 |
APOBEC3G
|
0.100 |
Biomarker
|
group |
BEFREE |
APOBEC3G could be important in modulating in vivo susceptibility to sexually transmitted HIV infection.
|
17330785 |
2007 |
APOBEC3G
|
0.100 |
Biomarker
|
group |
BEFREE |
Based on the ability of APOBEC3G to antagonize HIV infection, considerable interest hinges on elucidating its mechanism(s) of regulation.
|
16418394 |
2006 |
APOBEC3G
|
0.100 |
GeneticVariation
|
group |
BEFREE |
APOBEC3G genetic variants and their association with risk of HIV infection in highly exposed Caucasians.
|
16988524 |
2006 |
APOBEC3G
|
0.100 |
Biomarker
|
group |
BEFREE |
Members of the APOBEC family of cellular polynucleotide cytidine deaminases (e.g., APOBEC3G) are potent inhibitors of HIV infection.
|
17067930 |
2006 |
APOBEC3G
|
0.100 |
Biomarker
|
group |
BEFREE |
Then, with HIV-vif ineffective, apobec3G could act without hindrance to create a less aggressive, non-lethal HIV infection.Mutated vif impedes HIV infection.
|
15607551 |
2005 |
APOBEC3G
|
0.100 |
Biomarker
|
group |
BEFREE |
Mitogen activation induces the recruitment of LMM APOBEC3G into the HMM complex, and this correlates with a sharp increase in permissivity for HIV infection in these stimulated cells.
|
15829920 |
2005 |