Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.180 | GeneticVariation | disease | BEFREE | We describe the molecular analysis of the CD95 death domain in a family with autoimmune lymphoproliferative syndrome (Canale-Smith syndrome), T-cell lymphoma, and Hodgkin's disease. | 10340403 | 1999 | ||||
|
0.180 | Biomarker | disease | BEFREE | These results suggest possible hyper-expression of FAS/APO-1 (CD95) in Hodgkin's disease and anaplastic large cell lymphomas. | 8522287 | 1995 | ||||
|
0.180 | GeneticVariation | disease | BEFREE | Low frequency of FAS mutations in Reed-Sternberg cells of Hodgkin's lymphoma. | 12507887 | 2003 | ||||
|
0.180 | Biomarker | disease | BEFREE | As Hodgkin-Reed-Sternberg cells are resistant to CD95-mediated apoptosis and chromosomal aberrations involving the 1p22 region harbouring the proapoptotic BCL10 gene represent a recurrent event in Hodgkin's disease-derived cell lines, analysis of the BCL10 gene and its transcripts was performed. | 10848834 | 2000 | ||||
|
0.180 | GeneticVariation | disease | BEFREE | Individuals with germline mutations in the Fas gene have a high risk to develop non Hodgkin lymphomas (x 14) as well as Hodgkin lymphomas (x 51), in particular NLP Hodgkin lymphoma. | 15160902 | 2004 | ||||
|
0.180 | Biomarker | disease | BEFREE | These data demonstrate that caspase-3 expression plays an important role in CD95-mediated apoptosis in HD cell lines. | 11376869 | 2001 | ||||
|
0.180 | GeneticVariation | disease | BEFREE | No fas/APO-1 alterations were observed in the 31 HD cases. | 7572793 | 1995 | ||||
|
0.180 | GeneticVariation | disease | BEFREE | Because ALPS and NLP HL are both highly infrequent conditions, the occurrence in at least 3 families suggests a causative relationship between germline FAS gene mutations and NLP HL. | 11830507 | 2002 | ||||
|
0.180 | Biomarker | disease | HPO |