Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5966
Gene Symbol: REL
REL
0.550 Biomarker disease CTD_human A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). 21037568 2010
Entrez Id: 5966
Gene Symbol: REL
REL
0.550 Biomarker disease BEFREE In addition, c-rel has been activated by a retroviral promoter insertion in an avian B-cell lymphoma, and amplifications of REL (human c-rel) are frequently seen in Hodgkin's lymphomas and diffuse large B-cell lymphomas, and in some follicular and mediastinal B-cell lymphomas. 14755244 2004
Entrez Id: 5966
Gene Symbol: REL
REL
0.550 AlteredExpression disease LHGDN Our results demonstrate that there is differential c-REL protein expression in cHL in comparison with NLPHL and suggest that c-REL may play a role in the pathogenesis of classic Hodgkin lymphoma. 15551733 2004
Entrez Id: 5966
Gene Symbol: REL
REL
0.550 Biomarker disease BEFREE Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2. 12478664 2003
Entrez Id: 5966
Gene Symbol: REL
REL
0.550 AlteredExpression disease LHGDN Our data confirm previous cytogenetic results from primary Hodgkin's tumors suggesting an important pathogenic role of REL and JAK2 in this disease. 12478664 2003
Entrez Id: 5966
Gene Symbol: REL
REL
0.550 GeneticVariation disease LHGDN Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma. 11830502 2002
Entrez Id: 5966
Gene Symbol: REL
REL
0.550 Biomarker disease BEFREE BCL11A coamplified with REL in B-NHL cases and HD lymphoma cell lines with gains and amplifications of 2p13, suggesting that BCL11A may be involved in lymphoid malignancies through either chromosomal translocation or amplification. 11719382 2001
Entrez Id: 5966
Gene Symbol: REL
REL
0.550 GenomicAlterations disease CGI
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.460 Biomarker disease BEFREE GATA3 Immunohistochemical Staining in Hodgkin Lymphoma: Diagnostic Utility in Differentiating Classic Hodgkin Lymphoma From Nodular Lymphocyte Predominant Hodgkin Lymphoma and Other Mimicking Entities. 28877074 2019
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.460 GeneticVariation disease GWASCAT Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. 29196614 2017
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.460 Biomarker disease BEFREE Genes encoding the transcription factors GATA2, GATA3, MSX1 and SPIB - all basic lymphoid regulators - were identified as targets of SIX1 in HL. 26473286 2015
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.460 GeneticVariation disease GWASDB Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma. 24149102 2013
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.460 GeneticVariation disease GWASCAT Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma. 24149102 2013
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.460 Biomarker disease CTD_human A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). 21037568 2010
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.460 GeneticVariation disease GWASCAT A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). 21037568 2010
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.460 GeneticVariation disease BEFREE A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). 21037568 2010
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.460 AlteredExpression disease BEFREE Thus, GATA3 shapes the cytokine expression and signaling that is typical of HL. 20660789 2010
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.460 GeneticVariation disease GWASDB A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). 21037568 2010
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.460 AlteredExpression disease BEFREE Interestingly, the T cell transcription factor GATA-3 that is aberrantly expressed in HL was induced in most GC-LCLs and the memory B cell marker CD27 was activated in N-LCLs. 18430472 2008
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.460 Biomarker disease BEFREE Immunohistochemistry in HL tissues revealed that in 11 of 12 (92%) of the classical HL cases HRS cells were GATA-3 and/or T-bet positive. 15632006 2005
Entrez Id: 200942
Gene Symbol: KLHDC8B
KLHDC8B
0.410 Biomarker disease BEFREE PD-L1 expression was present in more than 5% of tumour or non-malignant HRS-like cells in 100% of EBV<sup>+</sup> classical (C) Hodgkin lymphoma (HL) (n = 10) and EBV-negative nodular sclerosis CHL (n = 8); 40% of EBV<sup>+</sup> diffuse large B cell lymphoma, not otherwise specified (DLBCL-NOS) (n = 20); and 4% of nodal peripheral T cell lymphoma of follicular helper T cell type (PTCL-TFH) (n = 22). 29380399 2018
Entrez Id: 200942
Gene Symbol: KLHDC8B
KLHDC8B
0.410 Biomarker disease CTD_human
Entrez Id: 200942
Gene Symbol: KLHDC8B
KLHDC8B
0.410 CausalMutation disease CLINVAR
Entrez Id: 200942
Gene Symbol: KLHDC8B
KLHDC8B
0.410 Biomarker disease HPO
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.400 AlteredExpression disease BEFREE Patients respond well to chemotherapy with cure rates of 80-90% and the recent finding of PD-L1 expression, an immune checkpoint, warrants the use of immunotherapy for some patients with recurrent and/or refractory HL. 31699300 2020