Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2641
Gene Symbol: GCG
GCG
0.100 Biomarker phenotype BEFREE Compared with high ET, low ET led to decreased GLP-1 (at all energy balance conditions: P < 0.001) and increased ghrelin concentrations (caloric restriction and overfeeding: P < 0.001), which was consistent with higher feelings of hunger (zero energy balance: P < 0.001) and desire to eat (all energy balance conditions: P < 0.05) and a positive energy balance during ad libitum intake (+17.5%; P < 0.001). 31305927 2019
Entrez Id: 2641
Gene Symbol: GCG
GCG
0.100 Biomarker phenotype BEFREE Within this sample of participants, the test meal was found to be associated with lower postprandial glycemia and insulinemia, higher GLP-1 serum concentrations, decreased hunger and desire to eat, and increased fullness. 31618605 2019
Entrez Id: 2641
Gene Symbol: GCG
GCG
0.100 GeneticVariation phenotype BEFREE To extend these findings, associations between perception of hunger and satiety with endocannabinoids, and with glucagon-like peptide-1 (GLP-1) and polypeptide YY (PYY) were assessed. 31546629 2019
Entrez Id: 2641
Gene Symbol: GCG
GCG
0.100 AlteredExpression phenotype BEFREE However, prior to the postprandial rise in GLP-1, levels of the hunger hormone, ghrelin, peak. 31311066 2019
Entrez Id: 2641
Gene Symbol: GCG
GCG
0.100 Biomarker phenotype BEFREE Untreated IGHD is associated with increased GLP-1 secretion and reduced postprandial ghrelin and hunger attenuation in response to a mixed meal. 30860584 2019
Entrez Id: 2641
Gene Symbol: GCG
GCG
0.100 AlteredExpression phenotype BEFREE Modified BPD does not lead to significant changes in satiety evaluated by the VAS; different aspects of satiety regulation are correlated with the postprandial levels of GLP-1 (hunger feeling) and GLP-2 (satiation feeling and desire to eat) 1 year after modified BPD, signaling a specific postoperative gut hormone-related modulation of appetite. 28808865 2018
Entrez Id: 2641
Gene Symbol: GCG
GCG
0.100 Biomarker phenotype BEFREE Whether suppression of plasma glucagon may contribute to increased hunger after weight loss and gradual weight regain is not yet known. 29144030 2018
Entrez Id: 2641
Gene Symbol: GCG
GCG
0.100 Biomarker phenotype BEFREE For GLP-1, a negative association for Hunger and a positive association for Satisfied and the Composite VAS score (all P < 0.05) were noted. 30096700 2018
Entrez Id: 2641
Gene Symbol: GCG
GCG
0.100 Biomarker phenotype BEFREE To investigate the association between postprandial plasma concentrations of amino acids and the anorexigenic hormones glucagon-like peptide-1 (GLP-1) and peptide tyrosine tyrosine (PYY), the orexigenic hormone ghrelin, and satiety and hunger in post-RYGB subjects. 29937240 2018
Entrez Id: 2641
Gene Symbol: GCG
GCG
0.100 Biomarker phenotype BEFREE Average GLP-1 was reduced at W4, and CCK was increased at 2 yr. After lifestyle-induced WL, patients with severe obesity will, therefore, have to deal with increased hunger in the long term. 29360396 2018
Entrez Id: 2641
Gene Symbol: GCG
GCG
0.100 Biomarker phenotype BEFREE To determine whether any sex difference in total PYY, GLP-1 or perceived hunger exists following moderate-intensity continuous exercise (MICT) and sprint interval exercise (SIT) METHODS: Twenty-one active participants (11 females) participated in three sessions in a randomized crossover design: (1) MICT, 30-min cycling at 65% VO<sub>2max</sub>; (2) SIT, 6 × 30 s "all-out" sprints with 4-min recovery periods; (3) control (CTRL; no exercise). 28154977 2017
Entrez Id: 2641
Gene Symbol: GCG
GCG
0.100 Biomarker phenotype BEFREE It was hypothesized that lower meal frequency in a reduced-energy regimen leading to greater body weight reduction and reduced hunger would be associated with decreased plasma concentrations of GIHs: gastric inhibitory peptide (GIP), glucagon-like peptide-1(GLP-1), peptide YY(PYY), pancreatic polypeptide (PP) and leptin and increased plasma concentration of ghrelin. 28369078 2017
Entrez Id: 2641
Gene Symbol: GCG
GCG
0.100 Biomarker phenotype BEFREE Outcome measures included gastric pouch emptying, glucose, insulin, and GLP-1; hunger, fullness, and stomach discomfort were measured by visual analogue scale. 29055668 2017
Entrez Id: 2641
Gene Symbol: GCG
GCG
0.100 AlteredExpression phenotype BEFREE To investigate differences in ad libitum food intake, feelings of hunger and satiety and the systemic levels of cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1), peptide YY (PYY), glucose and insulin after intraduodenal, intrajejunal and intraileal protein infusion. 27811949 2017
Entrez Id: 2641
Gene Symbol: GCG
GCG
0.100 Biomarker phenotype BEFREE These findings support a dose-response relationship between exercise intensity and total PYY, though the effects on total GLP-1 and hunger perceptions seem unclear. 27721013 2017
Entrez Id: 2641
Gene Symbol: GCG
GCG
0.100 AlteredExpression phenotype BEFREE Since hunger was also suppressed more efficiently, and serum GLP-1 levels were higher after one compared with five smaller drinks, our findings do not support nibbling to avoid hunger or to keep up EE from morning to noon. 28487141 2017
Entrez Id: 2641
Gene Symbol: GCG
GCG
0.100 Biomarker phenotype BEFREE Visual analog scale ratings of hunger and fullness and serial assessments of plasma glucose, insulin, and GLP-1 concentrations were done throughout the experiment. 25049134 2014
Entrez Id: 2641
Gene Symbol: GCG
GCG
0.100 AlteredExpression phenotype BEFREE Peptide YY (PYY), glucagon-like peptide 1 and ghrelin levels, as well as feelings of hunger and satiety, were determined pre- and postprandially in 62 women and 41 men (age 31+/-14 years; body mass index 25.0+/-3.1 kg/m(2)). 18957934 2008