Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 55893
Gene Symbol: ZNF395
ZNF395
0.010 Biomarker disease BEFREE Endogenous TARBP2 promotes metastatic cell invasion and colonization by destabilizing amyloid precursor protein (APP) and ZNF395 transcripts, two genes previously associated with Alzheimer's and Huntington's disease, respectively. 25043050 2014
Entrez Id: 7700
Gene Symbol: ZNF141
ZNF141
0.060 Biomarker disease BEFREE To explain these results, it was suggested that the HD locus (HD) lies close to the telomere and that a recombination event took place between HD and the most telomeric marker examined, D4S90. 1350884 1992
Entrez Id: 7700
Gene Symbol: ZNF141
ZNF141
0.060 GeneticVariation disease BEFREE Twelve Italian families with Huntington disease were tested with 10 probes known to be linked to the disease locus and able to detect polymorphisms at the following loci on chromosome 4: D4S10, D4S127, D4S95, D4S43, D4S115, D4S111, D4S90. 1829583 1991
Entrez Id: 7700
Gene Symbol: ZNF141
ZNF141
0.060 Biomarker disease BEFREE D4S95 is a most useful DNA marker for predictive testing programs, while D4S90 will serve as a useful starting point for identifying DNA fragments closer to the gene for HD. 2521771 1989
Entrez Id: 7700
Gene Symbol: ZNF141
ZNF141
0.060 Biomarker disease BEFREE Allelic frequencies of RFLPs at loci closely linked to the HD gene, D4S95, D4S91, D4S141, and D4S90, were determined in 13 Huntington's disease (HD) patients from nine Chinese families and 129 normal subjects. 7760321 1995
Entrez Id: 7700
Gene Symbol: ZNF141
ZNF141
0.060 Biomarker disease BEFREE A new DNA marker (D4S90) is located terminally on the short arm of chromosome 4, close to the Huntington disease gene. 2574148 1989
Entrez Id: 7700
Gene Symbol: ZNF141
ZNF141
0.060 Biomarker disease BEFREE These data suggest that it may be possible to construct high and low risk haplotypes, which may be helpful in DNA analysis and genetic counselling for HD, and represent independent evidence that the gene for HD is centromeric to more distally located DNA markers such as D4S90. 2531224 1989
Entrez Id: 64393
Gene Symbol: ZMAT3
ZMAT3
0.010 Biomarker disease BEFREE Together, we propose that Wig1, a key p53 downstream molecule in HD condition, play an important role in stabilizing mutant Htt mRNA and thereby accelerating HD pathology in the mHtt-p53-Wig1 positive feedback manner. 27206983 2016
Entrez Id: 100125288
Gene Symbol: ZGLP1
ZGLP1
0.010 Biomarker disease BEFREE Our findings collectively suggest that liraglutide can rescue impaired insulin signaling caused by mHTT and that GLP-1 may potentially reduce mHTT-induced neurotoxicity in the pathogenesis of HD. 30149534 2018
Entrez Id: 23390
Gene Symbol: ZDHHC17
ZDHHC17
0.270 AlteredExpression disease BEFREE Wildtype huntingtin (the protein mutated in HD) enhances the PAT activity of HIP14 and mutant HTT interacts less with HIP14. 22155432 2012
Entrez Id: 23390
Gene Symbol: ZDHHC17
ZDHHC17
0.270 Biomarker disease BEFREE Palmitoylation of CASP6 is decreased both in Hip14<sup>-/-</sup> mice, where HIP14 is absent, and in YAC128 mice, a model of Huntington disease, where HIP14 is dysfunctional and where CASP6 activity is increased. 27911442 2017
Entrez Id: 23390
Gene Symbol: ZDHHC17
ZDHHC17
0.270 Biomarker disease MGD Hip14 is dysfunctional in the presence of mutant htt in the YAC128 mouse model of HD, suggesting that altered palmitoylation mediated by HIP14 may contribute to HD. 21775500 2011
Entrez Id: 23390
Gene Symbol: ZDHHC17
ZDHHC17
0.270 Biomarker disease BEFREE Our findings suggest that decreased interaction between htt and HIP14 could contribute to the neuronal dysfunction in HD by perturbing normal intracellular transport pathways in neurons. 12393793 2002
Entrez Id: 23390
Gene Symbol: ZDHHC17
ZDHHC17
0.270 Biomarker disease BEFREE Nearly half of the 36 shared interactors are already implicated in HD, supporting a direct link between HIP14 and the disease. 24705354 2014
Entrez Id: 23390
Gene Symbol: ZDHHC17
ZDHHC17
0.270 AlteredExpression disease BEFREE HTT acts as a modulator of HIP14 activity such that in the presence of the HD mutation, HIP14 is less active. 25849918 2015
Entrez Id: 23390
Gene Symbol: ZDHHC17
ZDHHC17
0.270 Biomarker disease BEFREE Although some of the factors have been defined as genetic modifier factors in previous studies, none of the genes encoding GRIK2, TBP, BDNF and ZDHHC17 could be identified as a genetic modifier for HD. 16847693 2006
Entrez Id: 23390
Gene Symbol: ZDHHC17
ZDHHC17
0.270 Biomarker disease BEFREE We previously reported that mice lacking murine Hip14 (Hip14-/-) share features of HD. 22649491 2012
Entrez Id: 158866
Gene Symbol: ZDHHC15
ZDHHC15
0.010 Biomarker disease BEFREE In total six PATs (HIP14, HIP14L, ZDHHC8, ZDHHC9, ZDHHC12, and ZDHHC15) and one thioesterase (PPT1) have been implicated in Huntington disease (HD), Alzheimer disease, schizophrenia, mental retardation, and infantile and adult onset forms of neuronal ceroid lipofuscinosis. 22155432 2012
Entrez Id: 54503
Gene Symbol: ZDHHC13
ZDHHC13
0.220 Biomarker disease MGD In addition, HIP14L interacts less with mutant HTT than the wild-type protein, suggesting that reduced HIP14L-dependent palmitoylation of neuronal substrates may contribute to the pathogenesis of HD. 23077216 2013
Entrez Id: 54503
Gene Symbol: ZDHHC13
ZDHHC13
0.220 Biomarker disease BEFREE Preliminary evidence suggests a closely related PAT to HIP14, HIP14L, may also play a role in the pathogenesis of HD. 22155432 2012
Entrez Id: 54503
Gene Symbol: ZDHHC13
ZDHHC13
0.220 Biomarker disease BEFREE This suggests that altered HIP14-HTT and HIP14L-HTT interactions in the presence of the HD mutation reduces palmitoylation and promotes mislocalization of HTT and other HIP14/HIP14L substrates. 25849918 2015
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.020 AlteredExpression disease BEFREE Zbtb16 was upregulated in the DRN and it was the only gene that showed a correlated expression in the tgHD rats between SNc-VTA and DRN. 30711400 2019
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.020 AlteredExpression disease BEFREE This is accompanied by reduced autophagy (accumulation of p62) as the consequence of increased ZBTB16 expression and reduced ULK1 activity, as we have previously observed in Huntington's disease (HD). 29631635 2018
Entrez Id: 2547
Gene Symbol: XRCC6
XRCC6
0.010 Biomarker disease BEFREE These results collectively suggest that Ku70 is a critical regulator of DNA damage in HD pathology. 20439996 2010
Entrez Id: 7508
Gene Symbol: XPC
XPC
0.010 GeneticVariation disease BEFREE In order to assess whether single-nucleotide polymorphisms (SNPs) in the OGG1 and XPC genes, both implicated in responses to oxidative stress, are associated with the age of onset of HD, 9 SNPs have been genotyped in 299 individuals with HD and 582 controls. 23830927 2013