To further explore the physiological processes linked to metabolite imbalances during HD, we have investigated the 1D <sup>1</sup>H NMR spectroscopy-based metabolomics profile of Drosophila HD model.
We have used (1)H NMR metabolome profiling to characterize metabolic aberrations in a yeast model of Huntington's disease that are attributable to the mutant huntingtin protein's gain-of-toxic-function effects.
This chapter describes an assemblage of innovative NMR methods that have proved useful in detecting pathological cell dysfunctions in various preclinical models of HD.