| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.270 | AlteredExpression | disease | BEFREE | We aimed to assess the association between the expressions of AQP1 and AQP4 and the severity and duration of hydrocephalus after SAH. | 31556577 | 2019 | ||||
|
0.270 | AlteredExpression | disease | BEFREE | AQP-4 expression was higher in the sixth than in the first month after inoculation (P = 0.016) and also occurred in animals that received antigen inoculation but did not develop hydrocephalus, suggesting that AQP-4 may constitute an alternative route of cerebrospinal fluid absorption under inflammatory conditions. | 31470163 | 2019 | ||||
|
0.270 | Biomarker | disease | BEFREE | In a state of aquaporin-4 dysfunction such as in neuromyelitis optica, altered cerebrospinal fluid resorption could lead to acute hydrocephalus by a nonobstructive mechanism. | 31200081 | 2019 | ||||
|
0.270 | AlteredExpression | disease | BEFREE | RESULTS The hydrocephalus rat model was established successfully, and hydrocephalus rats showed a higher AQP4 level. | 29921834 | 2018 | ||||
|
0.270 | AlteredExpression | disease | BEFREE | Erythropoietin-mediated activation of aquaporin-4 channel for the treatment of experimental hydrocephalus. | 29982881 | 2018 | ||||
|
0.270 | AlteredExpression | disease | BEFREE | Significant increases in aquaporin-4 expression that occur over the course of animal aging, together with a reduced cerebrospinal fluid outflow rate and ventricular compliance, contribute to produce more severe hydrocephalus related to hypoxic events in aged mice, with a notable impairment in cognitive function. | 30293570 | 2018 | ||||
|
0.270 | ModifyingMutation | disease | RGD | With advancing hydrocephalus, expression of AQPs 1 and 4 increased at the brain-CSF interfaces; AQP1 was localized to the endothelium of cortical capillaries with increased AQP4 expression in surrounding astrocytes end feet. | 21135737 | 2011 | ||||
|
0.270 | Biomarker | disease | BEFREE | Here, we provide evidence for AQP4-facilitated CSF absorption in hydrocephalus by a transparenchymal pathway into the cerebral vasculature. | 16552421 | 2006 |