Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6336
Gene Symbol: SCN10A
SCN10A
0.620 Biomarker phenotype HPO
Entrez Id: 113189
Gene Symbol: CHST14
CHST14
0.100 Biomarker phenotype HPO
Entrez Id: 57555
Gene Symbol: NLGN2
NLGN2
0.200 Biomarker phenotype RGD "Unexpected association of the ""inhibitory"" neuroligin 2 with excitatory PSD95 in neuropathic pain." 23891900 2013
Entrez Id: 781
Gene Symbol: CACNA2D1
CACNA2D1
0.300 Biomarker phenotype CTD_human α2δ-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage. 24133248 2013
Entrez Id: 156
Gene Symbol: GRK2
GRK2
0.240 Biomarker phenotype BEFREE <b>Conclusion:</b> Low GRK2 in nociceptors is critical to develop a primed state in response to GDNF and leads to engagement of Epac signaling and transition to chronic PGE<sub>2</sub>-induced hyperalgesia. 29922165 2018
Entrez Id: 2668
Gene Symbol: GDNF
GDNF
0.320 Biomarker phenotype BEFREE <b>Results:</b> Glial cell-derived neurotrophic factor-induced hyperalgesia disappeared within 12 days. 29922165 2018
Entrez Id: 134391
Gene Symbol: GPR151
GPR151
0.010 GeneticVariation phenotype BEFREE <i>GPR151</i> mutation or spinal inhibition by shRNA alleviated SNL-induced mechanical allodynia and heat hyperalgesia. 30373770 2018
Entrez Id: 664
Gene Symbol: BNIP3
BNIP3
0.010 AlteredExpression phenotype BEFREE 3-MA aggravated hyperalgesia and allodynia and suppressed autophagy, while EDHB attenuated hyperalgesia and activated the autophagy procedure and the HIF-1<i>α</i> downstream target gene BNIP3. 29888265 2018
Entrez Id: 6863
Gene Symbol: TAC1
TAC1
0.380 Biomarker phenotype CTD_human Hyperalgesia during opioid abstinence: mediation by glutamate and substance p. 12351280 2002
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker phenotype CTD_human Hyperalgesia induced by both PLA(2)s was blocked by the histamine and serotonin receptor antagonists promethazine and methysergide, respectively, by the bradykinin B(2) receptor antagonist HOE 140 and by antibodies to tumor necrosis factor alfa (TNFalpha) and interleukin 1 (IL-1). 12727271 2003
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype CTD_human Hyperalgesia induced by both PLA(2)s was blocked by the histamine and serotonin receptor antagonists promethazine and methysergide, respectively, by the bradykinin B(2) receptor antagonist HOE 140 and by antibodies to tumor necrosis factor alfa (TNFalpha) and interleukin 1 (IL-1). 12727271 2003
Entrez Id: 3552
Gene Symbol: IL1A
IL1A
0.320 Biomarker phenotype CTD_human Hyperalgesia induced by both PLA(2)s was blocked by the histamine and serotonin receptor antagonists promethazine and methysergide, respectively, by the bradykinin B(2) receptor antagonist HOE 140 and by antibodies to tumor necrosis factor alfa (TNFalpha) and interleukin 1 (IL-1). 12727271 2003
Entrez Id: 4803
Gene Symbol: NGF
NGF
0.600 Biomarker phenotype BEFREE Hyperalgesia developed after NGF injection in the infrapatellar fat pad, but it was not facilitated by acid provocation. 27634419 2017
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype CTD_human Hyperalgesia induced by prostaglandin E2 remained unaffected by FR173657.5.Blood pressure reflexes following i.p. instillation of bradykinin in anaesthetized rats were inhibited by FR173657 s.c. with an ID50 of 1.1 micromol kg(-1), while the peptidic B2 antagonist icatibant (Hoe-140; D-Arg0-[Hyp3, Thi5, D-Tic7, Oic8]-bradykinin) caused inhibition at significantly lower doses (ID50 8.5 nmol kg(-1) P < 0.001).Responses to hydrochloric acid i.p. remained unaffected by FR173657.6. 9720808 1998
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.200 Biomarker phenotype RGD IL 2 may have accounted for such hyperalgesia. 12755376 2003
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
0.020 Biomarker phenotype BEFREE PAR2 activation also potentiated capsaicin-induced release of substance P and calcitonin gene-related peptide from superfused segments of the dorsal horn of the spinal cord, where they mediate hyperalgesia. 15128844 2004
Entrez Id: 55065
Gene Symbol: SLC52A1
SLC52A1
0.020 Biomarker phenotype BEFREE PAR2 activation also potentiated capsaicin-induced release of substance P and calcitonin gene-related peptide from superfused segments of the dorsal horn of the spinal cord, where they mediate hyperalgesia. 15128844 2004
Entrez Id: 885
Gene Symbol: CCK
CCK
0.220 Biomarker phenotype RGD Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance. 15647484 2005
Entrez Id: 5646
Gene Symbol: PRSS3
PRSS3
0.010 AlteredExpression phenotype BEFREE Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia. 17623652 2007
Entrez Id: 5646
Gene Symbol: PRSS3
PRSS3
0.010 Biomarker phenotype LHGDN Trypsin IV and p23 caused thermal hyperalgesia and mechanical allodynia and hyperalgesia in mice, and these effects were absent in PAR (-/-)(2) mice but maintained in PAR (-/-)(1) mice. 17623652 2007
Entrez Id: 729230
Gene Symbol: CCR2
CCR2
0.230 Biomarker phenotype RGD CCR2 RA-[R] treatment of nerve-injured rats produced stereospecific bilateral reversal of tactile hyperalgesia. 18076762 2007
Entrez Id: 134
Gene Symbol: ADORA1
ADORA1
0.200 Biomarker phenotype RGD Adenosine A1 receptor agonists reduce hyperalgesia after spinal cord injury in rats. 20065990 2010
Entrez Id: 4157
Gene Symbol: MC1R
MC1R
0.310 Biomarker phenotype BEFREE MC1R mutant females, and females overexpressing the endogenous MC1R antagonist, agouti signalling protein, had a reduced formalin-induced inflammatory pain response, and a delayed development of inflammation-induced hyperalgesia and allodynia. 20856883 2010
Entrez Id: 6336
Gene Symbol: SCN10A
SCN10A
0.620 Biomarker phenotype BEFREE SNS-GRK2+/- mice developed prolonged hyperalgesia in response to the Exchange proteins directly activated by cAMP (Epac) activator 8-pCPT-2'-O-Me-cAMP (8-pCPT). 20861385 2010
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
0.520 Biomarker phenotype CTD_human Interleukin-1 receptor antagonist ameliorates neonatal lipopolysaccharide-induced long-lasting hyperalgesia in the adult rats. 20937348 2011