Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8989
Gene Symbol: TRPA1
TRPA1
0.570 Biomarker phenotype BEFREE Accumulating evidences indicates that antagonists of TRPA1 and TRPM8 may protect against cisplatin, oxaliplatin, and paclitaxel-induced mitochondrial oxidative stress, inflammation, cold allodynia, and hyperalgesia. 29326595 2017
Entrez Id: 8989
Gene Symbol: TRPA1
TRPA1
0.570 Biomarker phenotype CTD_human Because TRPV1 and TRPA1 channels play important roles in controlling hyperalgesia in inflammatory pain models, we investigated their modulation by WIN and AM1241. 18234885 2008
Entrez Id: 8989
Gene Symbol: TRPA1
TRPA1
0.570 Biomarker phenotype RGD HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. 18954467 2008
Entrez Id: 8989
Gene Symbol: TRPA1
TRPA1
0.570 Biomarker phenotype BEFREE In conclusion, the actions of MG through TRPA1 activation on predominantly mechano-insensitive C fibers might be involved in spontaneously perceived pain in diabetic neuropathy and hyperalgesia as well as allodynia. 31219946 2019
Entrez Id: 8989
Gene Symbol: TRPA1
TRPA1
0.570 Biomarker phenotype BEFREE These findings support a critical involvement of TRPA1 channels in the pathophysiology of migraine, and show their active role in counteracting hyperalgesia at the trigeminal level. 28884307 2017
Entrez Id: 8989
Gene Symbol: TRPA1
TRPA1
0.570 Biomarker phenotype CTD_human Antagonism of the transient receptor potential ankyrin 1 (TRPA1) attenuates hyperalgesia and urinary bladder overactivity in cyclophosphamide-induced haemorrhagic cystitis. 23523557 2013
Entrez Id: 8989
Gene Symbol: TRPA1
TRPA1
0.570 Biomarker phenotype BEFREE PERSPECTIVE: This study demonstrates that the activation of Cavα2δ1 and the downstream PKC-TRPA1/GJ signaling pathway contributes greatly to trigeminal nerve injury-induced secondary mechanical and cold hyperalgesia. 31494272 2019
Entrez Id: 8989
Gene Symbol: TRPA1
TRPA1
0.570 Biomarker phenotype BEFREE The prevention of this hyperalgesia by diclofenac (1-10μg), the inhibitors of COX-1 SC-560 (0.1-1μg) or COX-2 celecoxib (1-5μg), the TRPV1 antagonist capsazepine (0.03-0.3μg) or the TRPA1 antagonist HC030031 (10-50μg) demonstrates the involvement of prostaglandin synthesis and TRP sensitization in CCL5-evoked hyperalgesia. 28126501 2017
Entrez Id: 8989
Gene Symbol: TRPA1
TRPA1
0.570 Biomarker phenotype CTD_human Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation. 21481532 2011
Entrez Id: 8989
Gene Symbol: TRPA1
TRPA1
0.570 Biomarker phenotype BEFREE Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia. 27434506 2016
Entrez Id: 8989
Gene Symbol: TRPA1
TRPA1
0.570 Biomarker phenotype BEFREE The observation that the TRPA1 irritant cinnamaldehyde induced heat hyperalgesia at an effect sizes comparable with that of capsaicin attributes TRPA1 a role in human heat-induced pain. 30664549 2019