Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.580 Biomarker phenotype BEFREE The aim of the current study was to investigate the effects of those two modalities on pain behavior and the expression of pro-inflammatory cytokines such as interleukin (IL)-1β and IL-6 and tumor necrosis factor-α (TNF-α) in the spinal cord and dorsal root ganglion (DRG) in a rat model of perioperative fentanyl induced hyperalgesia. 29657246 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.580 Biomarker phenotype RGD Dynamic response to peripheral nerve injury detected by in situ hybridization of IL-6 and its receptor mRNAs in the dorsal root ganglia is not strictly correlated with signs of neuropathic pain. 23953943 2013
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.580 Biomarker phenotype CTD_human Cytokine-mediated inflammatory hyperalgesia limited by interleukin-10. 7582491 1995
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.580 AlteredExpression phenotype BEFREE In this study, we tried to investigate behavioral hyperalgesia, the expression of proinflammatory cytokines, such as interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), and the activation of microglia in the spinal cord and dorsal root ganglion (DRG) in a rat model of surgical plantar incision with or without perioperative fentanyl. 29135586 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.580 Biomarker phenotype CTD_human Moreover, rolipram significantly potentiated hyperalgesia induced by carrageenan, bradykinin, TNF alpha, IL-1 beta, IL-6 and IL-8. 10401557 1999
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.580 Biomarker phenotype BEFREE Experimental FM caused bilateral hind paw hyperalgesia and augmented serum cortisol and muscle IL-6 concentrations. 30785911 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.580 Biomarker phenotype BEFREE Interleukin-6 Inhibitor Suppresses Hyperalgesia Without Improvement in Osteoporosis in a Mouse Pain Model of Osteoporosis. 30666355 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.580 Biomarker phenotype BEFREE The involvement of corticotropin-releasing factor (CRF), Type 2 CRF receptor (CRF<sub>2</sub>) and inflammatory cytokine interleukin-6 (IL-6) was also investigated in the gastric hyperalgesia observed in this model. 31558322 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.580 Biomarker phenotype BEFREE Finally, knockdown of the IL-6 receptor signaling subunit glycoprotein 130 (gp130) attenuated both vibration-induced muscle hyperalgesia and downregulation of KV1.4. 31335655 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.580 Biomarker phenotype BEFREE Treatment with anti-IL-6 or anti-IL-6R agents seems to alleviate allodynia and hyperalgesia, so it may be a valid option when treating the many conditions involving pathological pain as rheumatoid arthritis. 31536783 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.580 Biomarker phenotype CTD_human The critical role of invading peripheral macrophage-derived interleukin-6 in vincristine-induced mechanical allodynia in mice. 18652822 2008
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.580 Biomarker phenotype BEFREE We used mice lacking D5Rs (<i>DRD5KO</i> mice) to show that carrageenan, interleukin 6, as well as BDNF-induced hyperalgesia and priming are reduced specifically in male mice. 29167404 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.580 Biomarker phenotype RGD Effect of tramadol on immune responses and nociceptive thresholds in a rat model of incisional pain. 18988309 2008