Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression phenotype BEFREE These results suggest that minocycline provides protection against neonatal systemic LPS exposure-induced enhanced pain sensitivity (allodynia and hyperalgesia), and that the protective effects may be associated with its ability to attenuate LPS-induced microglia activation, and the levels of IL-1β, COX-2, and PGE2 in the spinal cord of neonatal rats. 30262747 2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker phenotype BEFREE Selective for COX-2 over COX-1, compound 10 exhibited IC<sub>50</sub> 0.02 µM for COX-2 and reversed acetic acid induced inflammation in rats by 73% when used at 10 mg kg<sup>-1</sup> dose and the same dose of the compound also rescued the animals from inflammatory phase of formalin induced hyperalgesia. 31843462 2020
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker phenotype BEFREE This study investigated whether 14 days of the selective Cox-2 inhibitor etoricoxib (60 mg/day) would modify self-report of pain intensity and quality, and physical measures of hyperalgesia and function in individuals with knee OA. 28778815 2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker phenotype CTD_human The results of the study suggest participation of COX-1, COX-2 and iNOS, but not nNOS, in transmission of pain stimuli in STZ-induced diabetic hyperalgesia. 17989504 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 GeneticVariation phenotype BEFREE The prevention of this hyperalgesia by diclofenac (1-10μg), the inhibitors of COX-1 SC-560 (0.1-1μg) or COX-2 celecoxib (1-5μg), the TRPV1 antagonist capsazepine (0.03-0.3μg) or the TRPA1 antagonist HC030031 (10-50μg) demonstrates the involvement of prostaglandin synthesis and TRP sensitization in CCL5-evoked hyperalgesia. 28126501 2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 GeneticVariation phenotype BEFREE The effects of the COX-2 inhibitor, parecoxib (intraperitoneal 10 mg kg<sup>-1</sup>), or the EP-1R antagonist, SC51089 (intraperitoneal 100 μg kg<sup>-1</sup>), on hyperalgesia and spinal PGE2 were examined. 29576123 2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression phenotype BEFREE Peripheral but not central activation of cyclooxygenase-2 (Cox-2) were critical for CCL2-induced hyperalgesia. 23683582 2013
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker phenotype BEFREE Moreover, TMJ inflammation-induced upregulation of Na<sub>v</sub>1.7 expression and PGE<sub>2</sub> levels in the TG could be reversed by COX-2-selective inhibitor meloxicam given by oral gavage, and meanwhile, the hyperalgesia of inflamed TMJ was also mitigated. 28349234 2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression phenotype BEFREE Multiple pro-inflammatory cytokines and mediators are produced during neurogenic inflammation and aberrant control of COX-2 mRNA turnover may be implicated in diseases including chronic inflammation, which results in inflammation-derived hyperalgesia around primary sensory neurons. 30528878 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker phenotype BEFREE The objective of this research was to investigate the role of COX-2 in remifentanil-induced hyperalgesia and its relationship with ephrinB/EphB signaling. 30759061 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker phenotype RGD We also aimed to investigate whether celecoxib, a specific cyclooxygenase 2 (COX-2) inhibitor, would affect secondary hyperalgesia. 15464832 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker phenotype BEFREE In addition to arachidonic acid, COX-2 oxidizes the endocannabinoid 2-arachidonoylglycerol (2-AG) to produce prostaglandin E<sub>2</sub> (PGE<sub>2</sub>)-glycerol (PGE<sub>2</sub>-G); PGE<sub>2</sub>-G is known to produce hyperalgesia. 30796025 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker phenotype CTD_human These results indicate that intrathecal administration of COX-2 inhibitors has an anti-hyperalgesic effect on streptozotocin-induced mechanical hyperalgesia and we concluded that spinal COX-2 is pivotal in streptozotocin-induced hyperalgesia. 17112505 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker phenotype BEFREE Suppression of hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia following systemic administration of lutein via inhibition of cyclooxygenase-2 cascade signaling. 30498399 2018