Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype CTD_human Pertussis toxin prevented the inhibition of BK-induced hyperalgesia by U50,488H, DPDPE, or DAMGO. 2010815 1991
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype CTD_human Arachidonic acid induces a dose-dependent hyperalgesia that was found to be like bradykinin-hyperalgesia in untreated skin (prostaglandin E2-mediated and phospholipase A2-dependent). 2128375 1990
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype CTD_human These data are compatible with the suggestion that the prostaglandin products mediating BK and NE hyperalgesia differ, BK hyperalgesia being mediated by PGE2 and NE hyperalgesia by PGI2. 3061568 1988
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype CTD_human BW373U86, a delta-opioid receptor agonist, reverses bradykinin-induced thermal allodynia in rhesus monkeys. 7493622 1995
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype CTD_human These data suggest that IL-10 limits the inflammatory hyperalgesia evoked by carrageenin and bradykinin by two mechanisms: inhibition of cytokine production and inhibition of IL-1 beta evoked PGE2 production. 7582491 1995
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype CTD_human Post-treatment with S14080 dose-dependently antagonized the hyperalgesia induced by prostaglandin E2, bradykinin, dopamine and by the hyperalgesic cytokines reported to be released by carrageenin (tumour necrosis factor alpha, interleukin-1 and interleukin-8).3. 7881729 1995
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype CTD_human The HE (3 to 100 mg kg(-1), p.o., 1 h) inhibited in a graded manner, the hyperalgesia induced by bradykinin (3 nmol/paw) or substance P (10 nmol/paw) in rat paw, with mean ED50 values of 54.5 and 53.7 mg kg(-1), respectively. 9714424 1998
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype CTD_human Hyperalgesia induced by prostaglandin E2 remained unaffected by FR173657.5.Blood pressure reflexes following i.p. instillation of bradykinin in anaesthetized rats were inhibited by FR173657 s.c. with an ID50 of 1.1 micromol kg(-1), while the peptidic B2 antagonist icatibant (Hoe-140; D-Arg0-[Hyp3, Thi5, D-Tic7, Oic8]-bradykinin) caused inhibition at significantly lower doses (ID50 8.5 nmol kg(-1) P < 0.001).Responses to hydrochloric acid i.p. remained unaffected by FR173657.6. 9720808 1998
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype CTD_human Moreover, rolipram significantly potentiated hyperalgesia induced by carrageenan, bradykinin, TNF alpha, IL-1 beta, IL-6 and IL-8. 10401557 1999
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype CTD_human GAEE significantly inhibited the hyperalgesia induced by bradykinin or substance P in rat paw, but did not affect the hyperalgesia caused by carrageenan or prostaglandin E2. 10499367 1999
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype CTD_human Given orally NPC 18884, but not HOE 140, caused graded inhibition of BK-induced nociception (mean ID50 value of 50 nmol/kg).In rats, NPC 18884 given i.p. prevented BK and carrageenan-induced hyperalgesia (mean ID50 values of 6 nmol/kg and 13 nmol/kg), without affecting the hyperalgesia induced by des-Arg9-bradykinin (DABK) or by prostaglandin E2 (PGE2).NPC 18884 given i.p. inhibited the mouse paw oedema induced by tyrosine8-bradykinin or by carrageenan, but had no effect on DABK-induced oedema in mice pre-treated with Escherichia coli endotoxin, or that induced by PGE2. 10543429 1999
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype CTD_human Antinociceptive properties of mixture of alpha-amyrin and beta-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways. 15626726 2005
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype CTD_human In addition, the ME of B. microstachya (3--300 mg kg(-1), i.p., 30 min earlier) inhibited, in a graded manner, the hyperalgesia induced by bradykinin (3.2 microg/paw), substance P (13.5 microg/paw), carrageenan (300 microg/paw), capsaicin (100 microg/paw) and adrenaline (100 ng/paw) in the rat paw, with mean ID50 values of 20.5, 17.9, 101.8, 54.2 and 99.7 mg kg(-1), respectively. 16259764 2005
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype CTD_human In wild-type mice, activation of PKRs by the PKR agonist Bv8 caused hyperalgesia and sensitized to the actions of capsaicin. pkr1-null mice exhibited impaired responses to Bv8 but showed normal hyperalgesic responses to bradykinin and PGE2 (prostaglandin E2). 16793879 2006
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype CTD_human Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia. 18234883 2008
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype CTD_human Evidence of TRPV1 receptor and PKC signaling pathway in the antinociceptive effect of amyrin octanoate. 19646975 2009
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype RGD P2X3 and P2X2/3 receptors mediate mechanical hyperalgesia induced by bradykinin, but not by pro-inflammatory cytokines, PGE₂ or dopamine. 20868656 2010
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype CTD_human Sex differences in behavior and expression of CGRP-related genes in a rodent model of chronic migraine. 21521205 2011
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype BEFREE Heightened nociceptor function caused by inflammatory mediators such as bradykinin (BK) contributes to increased pain sensitivity (hyperalgesia) to noxious mechanical and thermal stimuli. 22921401 2012
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype BEFREE Inflammatory mediators such as prostaglandin-E2 or bradykinin cause hyperalgesia by activating cellular kinases that phosphorylate TRPV1, a process that has recently been shown to rely on a scaffolding protein, AKAP79, to target the kinases to TRPV1. 23699529 2013
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype BEFREE IS comprises an acidic combination of bradykinin, serotonin, histamine and prostaglandin PGE2 and was introduced to basic pain research as a tool to activate and sensitize peripheral nociceptors when studying pathological pain conditions associated with allodynia and hyperalgesia. 28167076 2017
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype BEFREE Dexamethasone (glucocorticoid anti-inflammatory agent), DALBK (bradykinin B1 antagonist), Atenolol (β1 adrenoceptor antagonist), ICI 118,551 (β2 adrenoceptor antagonist), indomethacin (cyclooxygenase inhibitor), and fucoidan (non-specific selectin inhibitor) all reduced static contraction-induced muscle hyperalgesia; however, the bradykinin B2 antagonist, bradyzide, did not have an effect on static contraction-induced muscle hyperalgesia. 28673715 2017
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 Biomarker phenotype BEFREE P2 × 7 receptor-induced articular hyperalgesia is sustained by the involvement of this purinergic receptor in bradykinin and dopamine-induced hyperalgesia in the knee joint. 29260240 2018
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.560 AlteredExpression phenotype BEFREE Synergistic expression of cyclooxygenase-2 (COX-2) by interleukin-1β (IL-1β) and bradykinin (BK) in peri-sensory neurons results in the production of prostanoids, which affects sensory neuronal activity and responsiveness and causes hyperalgesia. 30528878 2019