Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 887
Gene Symbol: CCKBR
CCKBR
0.510 Biomarker phenotype RGD Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance. 15647484 2005
Entrez Id: 887
Gene Symbol: CCKBR
CCKBR
0.510 Biomarker phenotype CTD_human Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system. 11880531 2002
Entrez Id: 887
Gene Symbol: CCKBR
CCKBR
0.510 Biomarker phenotype BEFREE RVM microinjection of the CCK2 receptor agonist CCK-8 and intrathecal injection of the 5-HT2B receptor agonist BW723C86 both produced hyperalgesia in female rats after plantar incision, whereas the CCK2 receptor antagonist YM022, the 5-HT2B receptor antagonist RS127445, and the PKCγ inhibitor C37H65N9O13 decreased the rats' sensitivity to the same stimulus. 31308730 2019