Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.520 Biomarker phenotype BEFREE In the present research, neuropathic pain induced Nrf2 and HO-1 expression in the microglial cells of the spinal cord; Nrf2 and HO-1 were necessary to alleviate the hyperalgesia of CCI-induced rats; NaHS mitigated the hyperalgesia and allodynia induced by the CCI operation; and NaHS mitigated the excessive release of the cytokines TNF-α, IL-1β, IL-6 and HMGB1 via the Nrf2/HO-1 pathway in the microglial cells of the spinal cord. 31325725 2019
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.520 Therapeutic phenotype RGD Overexpression of miR-381 relieves neuropathic pain development via targeting HMGB1 and CXCR4. 30142543 2018
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.520 Biomarker phenotype BEFREE In the present study, we examined the theory that PKC activation lead to nuclear translocation and cytosolic HMGB1 secretion, which subsequently induces spinal neuro inflammatory responses (cytokine release) causing hyperalgesia. 29428215 2018
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.520 Biomarker phenotype CTD_human Tissue protein levels were determined by immunoblotting.Repeated i.p. administration of the anti-HMGB1-neutralizing antibody or recombinant human soluble thrombomodulin (rhsTM), known to inactivate HMGB1, prevented the development of hyperalgesia and/or allodynia induced by paclitaxel or vincristine in rats.A single i.p. or intraplantar (i.pl.) administration of the antibody or rhsTM reversed the chemotherapy-induced neuropathy.A single i.pl. administration of a TLR4 antagonist or low molecular weight heparin, known to inhibit RAGE, attenuated the hyperalgesia caused by i.pl. 27474498 2016
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.520 Therapeutic phenotype RGD Intrathecal lentivirus-mediated transfer of interleukin-10 attenuates chronic constriction injury-induced neuropathic pain through modulation of spinal high-mobility group box 1 in rats. 24077211 2014