Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE TRPV1 was responsible from the cisplatin-induced heat hyperalgesia and mechanical allodynia in the sensory neurons. 29326595 2017
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE TRPV1 contributes to peripheral sensitization and hyperalgesia, in part, <i>via</i> triggering the release of proinflammatory peptides, such as calcitonin gene-related peptide (CGRP), both locally and at the dorsal horn of the spinal cord. 31551772 2019
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE A strong connection has been suggested between the expression of the transient receptor potential vanilloid type 1 (TRPV1) ion channel and the development of inflammatory hyperalgesia. 26176938 2015
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE Ablation of TRPV1-expressing fibers prevented facial hyperalgesia in diabetic rats. 28606782 2017
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 AlteredExpression phenotype BEFREE Activation of TRPV1 receptors and NGF-signaling pathways may contribute to heat hyperalgesia induced by ET-1. 28865353 2017
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE Altogether, these results indicate that B vitamins can be useful to control heat hyperalgesia associated with trigeminal neuropathic pain and that modulation of TRPV1 receptors may contribute to their anti-hyperalgesic effects. 26048309 2015
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype CTD_human Because TRPV1 and TRPA1 channels play important roles in controlling hyperalgesia in inflammatory pain models, we investigated their modulation by WIN and AM1241. 18234885 2008
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype CTD_human Because animals treated with opiates show thermal hyperalgesia, we examined the possible role of TRPV1 receptors in the development of morphine-induced hyperalgesia using TRPV1 wild-type (WT) and knock-out (KO) mice and with administration of a TRPV1 antagonist in mice and rats. 18774343 2009
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE Beneficial effect of mirtazapine on diabetes-induced hyperalgesia: involvement of TRPV1 and ASIC1 channels in the spinal cord and dorsal root ganglion. 30822229 2019
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE By precisely removing a unique PKC phosphorylation site (TRPV1 S801) in mice through CRISPR/Cas9 editing, we provide <i>in vivo</i> evidence for a highly specific inhibition that leaves basal TRPV1 function intact, yet alleviates some forms of hyperalgesia. 31676602 2019
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 AlteredExpression phenotype BEFREE CFA-induced inflammatory hyperalgesia did not alter TRPV1 expression in the trigeminal ganglia from male rats. 29209900 2018
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE Following TNBS treatment, the successive administration of the transient receptor potential vanilloid 1 (TRPV1) antagonist SB366791 or neutralizing anti-Artn antibody completely inhibited the heat hyperalgesia. 26270588 2015
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE Ghrelin attenuated hyperalgesia induced by chronic nitroglycerin: CGRP and TRPV1 as targets for migraine management. 29237283 2018
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE Importantly, we found that interfering with TRPV1 subunit association using a plasma membrane-tethered peptide attenuated mechanical and thermal hypersensitivity in two mouse models of inflammatory hyperalgesia. 24808184 2014
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 AlteredExpression phenotype BEFREE In CP-W, pinprick hyperalgesia and increased sensitivity to capsaicin were aligned with increased epidermal TRPV1 expression, while smaller histamine axon reflex erythema matched with significantly reduced intraepidermal nerve fiber density. 30938826 2019
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 AlteredExpression phenotype BEFREE In summary, our results demonstrate an increased activity of TRPV1 in DRG neurons as a new mechanism contributing to opioid withdrawal-induced hyperalgesia. 23398938 2013
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE In vivo, local administration of TRPV1 antagonists into the lateral habenula attenuated hyperalgesia, anxiety, and relapse-like drinking in rats who chronically consumed alcohol.The data suggest that enhanced TRPV1 channel function during withdrawal may contribute to aberrant behavior that promotes relapse alcohol consumption. 30676422 2019
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE Inflammation induces Epac-protein kinase C alpha and epsilon signaling in TRPV1-mediated hyperalgesia. 30015706 2018
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 AlteredExpression phenotype BEFREE Intrathecal administration of the TRPV1 siRNA not only attenuated behavioural hyperalgesia but also reduced the expression of TRPV1 and CAMKII, as well as ERK2 phosphorylation. 30808963 2019
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE Involvement of TRPM2 and TRPV1 channels on hyperalgesia, apoptosis and oxidative stress in rat fibromyalgia model: Protective role of selenium. 29235496 2017
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE It has been revealed that TRPM8 activation leads to a decline in TRPV1 activity, which may be of therapeutic benefit in clinical circumstances such as treatment of TRPV1-mediated inflammatory hyperalgesia, colitis, and dry eye syndrome. 28861042 2017
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE Moxibustion relieves visceral hyperalgesia via inhibition of transient receptor potential vanilloid 1 (TRPV1) and heat shock protein (HSP) 70 expression in rat bone marrow cells. 26338695 2016
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 AlteredExpression phenotype BEFREE Notably, intrathecal administration of the interfering peptide against the phosphorylation of Thr-406 alleviated heat hyperalgesia and reduced the surface level of TRPV1 in inflammatory pain rats. 26376215 2015
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 PosttranslationalModification phenotype BEFREE Oral administration of curcumin attenuates visceral hyperalgesia through inhibiting phosphorylation of TRPV1 in rat model of ulcerative colitis. 28812431 2018
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 AlteredExpression phenotype BEFREE Our data suggest that H<sub>2</sub>S leads to hyperalgesia in diabetic rats through activation of TRPV1, TRPA1 and TRPC channels and, subsequent intraepidermal fibers loss. 30602386 2019