Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Selective astrocyte (α-aminoadipate) and microglia (minocycline) inhibitors were injected i.t. to determine the contribution of these cells to hyperalgesia and paw edema.The effects of i.t. treatments with glial and NFκB (PDTC) inhibitors on spinal glial activation, TNF-α, IL-1β, CX<sub>3</sub>CR1 and CX<sub>3</sub>CL1 mRNA expression, and NFκB activation were also evaluated. 31138231 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker phenotype BEFREE In addition to arachidonic acid, COX-2 oxidizes the endocannabinoid 2-arachidonoylglycerol (2-AG) to produce prostaglandin E<sub>2</sub> (PGE<sub>2</sub>)-glycerol (PGE<sub>2</sub>-G); PGE<sub>2</sub>-G is known to produce hyperalgesia. 30796025 2019
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 AlteredExpression phenotype BEFREE The aim of this study is the contribution of TRPV1 to the surface expression of <i>N</i>-methyl-d-aspartate (NMDA) receptors in remifentanil-induced postoperative hyperalgesia. 30863139 2019
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE Selective pharmacological blockade of TRPA1 or TRPV1 showed that TRPA1 is crucially involved in MG-induced chemical pain sensation and heat hyperalgesia. 31219946 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 AlteredExpression phenotype BEFREE Selective astrocyte (α-aminoadipate) and microglia (minocycline) inhibitors were injected i.t. to determine the contribution of these cells to hyperalgesia and paw edema.The effects of i.t. treatments with glial and NFκB (PDTC) inhibitors on spinal glial activation, TNF-α, IL-1β, CX<sub>3</sub>CR1 and CX<sub>3</sub>CL1 mRNA expression, and NFκB activation were also evaluated. 31138231 2019
Entrez Id: 4803
Gene Symbol: NGF
NGF
0.600 Biomarker phenotype BEFREE Nerve growth factor (NGF) has been implicated in hyperalgesia by sensitising nociceptors. 31383364 2019
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE By precisely removing a unique PKC phosphorylation site (TRPV1 S801) in mice through CRISPR/Cas9 editing, we provide <i>in vivo</i> evidence for a highly specific inhibition that leaves basal TRPV1 function intact, yet alleviates some forms of hyperalgesia. 31676602 2019
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE In vivo, local administration of TRPV1 antagonists into the lateral habenula attenuated hyperalgesia, anxiety, and relapse-like drinking in rats who chronically consumed alcohol.The data suggest that enhanced TRPV1 channel function during withdrawal may contribute to aberrant behavior that promotes relapse alcohol consumption. 30676422 2019
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE TRPV1 contributes to peripheral sensitization and hyperalgesia, in part, <i>via</i> triggering the release of proinflammatory peptides, such as calcitonin gene-related peptide (CGRP), both locally and at the dorsal horn of the spinal cord. 31551772 2019
Entrez Id: 4803
Gene Symbol: NGF
NGF
0.600 Biomarker phenotype BEFREE Nerve growth factor-induced muscle hyperalgesia facilitates ischaemic contraction-evoked pain. 31314952 2019
Entrez Id: 4803
Gene Symbol: NGF
NGF
0.600 Biomarker phenotype BEFREE Development of hyperalgesia may be associated with an increase in NGF as well as increased inflammatory mediators. 31152170 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression phenotype BEFREE These results suggest that minocycline provides protection against neonatal systemic LPS exposure-induced enhanced pain sensitivity (allodynia and hyperalgesia), and that the protective effects may be associated with its ability to attenuate LPS-induced microglia activation, and the levels of IL-1β, COX-2, and PGE2 in the spinal cord of neonatal rats. 30262747 2018
Entrez Id: 4803
Gene Symbol: NGF
NGF
0.600 AlteredExpression phenotype BEFREE Pressure stimulation, contact heat stimulation, hyperalgesia (pinprick stimulation) and allodynia (brush stimulation) to mechanical stimulation were performed in the area where capsaicin and NGF were injected. 29498480 2018
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE Similarly, NTG injection produced significant hindpaw mechanical allodynia or facial cold allodynia, but not heat hyperalgesia in transient receptor potential type V1 (TRPV1) knockout mice. 29187670 2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 GeneticVariation phenotype BEFREE The effects of the COX-2 inhibitor, parecoxib (intraperitoneal 10 mg kg<sup>-1</sup>), or the EP-1R antagonist, SC51089 (intraperitoneal 100 μg kg<sup>-1</sup>), on hyperalgesia and spinal PGE2 were examined. 29576123 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression phenotype BEFREE Rats treated with pre-incision LIA and SNB or post-incision LIA had alleviated hyperalgesia and significantly reduced levels of IL-1β, IL-6, and TNF-α compared to the control group. 29657246 2018
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 PosttranslationalModification phenotype BEFREE Oral administration of curcumin attenuates visceral hyperalgesia through inhibiting phosphorylation of TRPV1 in rat model of ulcerative colitis. 28812431 2018
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE SZV 1287 significantly inhibited both TRPA1 and TRPV1 activation-induced acute chemonociception and hyperalgesia. 29438782 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE The present findings indicate that the BDNF and IL-1ß induction within the dorsal horn may be linked to the development of hyperalgesia, and that opioid analgesics and probably inhibitors of glial cell activation can prevent sensitization in the pain pathway at spinal level. 29217257 2018
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 AlteredExpression phenotype BEFREE CFA-induced inflammatory hyperalgesia did not alter TRPV1 expression in the trigeminal ganglia from male rats. 29209900 2018
Entrez Id: 4803
Gene Symbol: NGF
NGF
0.600 Biomarker phenotype BEFREE Intraplantar injection of NGF<sup>R100W</sup> into adult rats induced neither TrkA-mediated thermal nor mechanical acute hyperalgesia, but retained the ability to induce chronic hyperalgesia based on agonism for TrkA signaling. 29483280 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker phenotype BEFREE The aim of the current study was to investigate the effects of those two modalities on pain behavior and the expression of pro-inflammatory cytokines such as interleukin (IL)-1β and IL-6 and tumor necrosis factor-α (TNF-α) in the spinal cord and dorsal root ganglion (DRG) in a rat model of perioperative fentanyl induced hyperalgesia. 29657246 2018
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE We studied the possible role of TRPV1 and TRPV4 in transducing cancer-induced hyperalgesia. 29637027 2018
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE Ghrelin attenuated hyperalgesia induced by chronic nitroglycerin: CGRP and TRPV1 as targets for migraine management. 29237283 2018
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.600 Biomarker phenotype BEFREE Inflammation induces Epac-protein kinase C alpha and epsilon signaling in TRPV1-mediated hyperalgesia. 30015706 2018