| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.540 | Biomarker | phenotype | BEFREE | We assessed hyperalgesia, histopathological changes, immunoreactive (-ir) neurons for calcitonin gene-related peptide and activating transcription factor 3 in DRG, and immunoreactive neurons for ionized-calcium-binding adaptor molecule 1 (Iba1) in the dorsal horn of the spinal cord. | 31538672 | 2020 | ||||
|
0.540 | Biomarker | phenotype | BEFREE | Results revealed that increased hyperalgesia was concurrent with an increment of Iba1 (P < 0.001), TNF-α (P < 0.001), PTEN (P < 0.01), cleaved caspase-3 (P < 0.001), and a decrement of P.Akt (P < 0.01) during the acute phase of CFA-induced inflammation, while, at the same time as decreasing hyperalgesia during the chronic phase of study, Iba1 and TNF-α expression significantly decreased and PTEN, cleaved caspase-3, and P.Akt restored to baseline on day 0. | 31388881 | 2020 | ||||
|
0.540 | Biomarker | phenotype | BEFREE | Behavioral tests revealed allodynia, ongoing pain, and increased expression of c-fos, GFAP, and Iba1, as well as the absence of hyperalgesia in Burn7s. | 28181986 | 2018 | ||||
|
0.540 | Biomarker | phenotype | BEFREE | Immunohistochemical analysis showed that spinal microglia were activated and that the P2X4R level was increased and colocalized with ionized calcium-binding adapter molecule 1 in NTW-induced hyperalgesia. | 28306606 | 2017 | ||||
|
0.540 | Biomarker | phenotype | CTD_human | Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK. | 27093858 | 2016 | ||||
|
0.540 | Biomarker | phenotype | RGD | Involvement of microglia in the ethanol-induced neuropathic pain-like state in the rat. | 17284346 | 2007 |