| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.360 | Biomarker | phenotype | BEFREE | Male Wistar rats were pretreated with the selective P2X3 receptor antagonist, A-317491, by intramuscular or intrathecal injection and the static contraction-induced mechanical muscle hyperalgesia was evaluated using the Randall-Selitto test. | 31115830 | 2019 | ||||
|
0.360 | Biomarker | phenotype | BEFREE | Immunostaining assays did not reveal significant increases in the percentage of P2X3-positive neurons, indicating that increased P2X3-R at DRG somas is not critical for inducing inflammatory hyperalgesia in CFA-treated rats. | 29219199 | 2018 | ||||
|
0.360 | Biomarker | phenotype | BEFREE | To explore the role of P2X2 and P2X3 receptors in the opioid-induced hyperalgesia, heroin self-administration rats were adopted, and the thermal and mechanical nociceptive thresholds were evaluated using the paw withdrawal test after abstinence from heroin for 8 days. | 29596152 | 2018 | ||||
|
0.360 | Biomarker | phenotype | BEFREE | P2 × 7 receptor-induced articular hyperalgesia is sustained by the involvement of this purinergic receptor in bradykinin and dopamine-induced hyperalgesia in the knee joint. | 29260240 | 2018 | ||||
|
0.360 | Biomarker | phenotype | BEFREE | These findings indicate that P2X3 and P2X2/3 receptors activation by endogenous ATP is essential to hyperalgesia development in the knee joint through an indirect sensitization of primary afferent nociceptors dependent on the previous release of pro-inflammatory cytokines and/or on neutrophil migration. | 27709491 | 2017 | ||||
|
0.360 | Biomarker | phenotype | BEFREE | Visceromotor responses (VMR) and the abdominal withdrawal reflexes (AWR) to colorectal distention (CRD) were recorded to determine P2X3-receptor-mediated alteration of hyperalgesia following single-prolonged stress (SPS) exposure. | 27781340 | 2017 | ||||
|
0.360 | Biomarker | phenotype | CTD_human | Modulation of P2X receptors in dorsal root ganglion neurons of streptozotocin-induced diabetic neuropathy. | 19383439 | 2009 |