Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.340 Biomarker phenotype BEFREE These results indicate that the absence of the NOP receptor protects males from traumatic-stress-induced allodynia and hyperalgesia, consistent with our previous findings utilizing a NOP receptor antagonist. 30670988 2018
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.340 Biomarker phenotype BEFREE Our findings suggest that the spinal NOP receptor system attenuates injury-induced hyperalgesia by direct inhibition of the projection neurons in the spinal cord that send nociceptive signals to the brain and not by inhibiting presynaptic terminals of DRG neurons in the superficial lamina. 29582417 2018
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.340 Biomarker phenotype CTD_human Antinociceptive effects of nociceptin/orphanin FQ administered intrathecally in monkeys. 19231294 2009
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.340 Biomarker phenotype CTD_human Nocistatin and prepro-nociceptin/orphanin FQ 160-187 cause nociception through activation of Gi/o in capsaicin-sensitive and of Gs in capsaicin-insensitive nociceptors, respectively. 12665541 2003
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.340 Biomarker phenotype BEFREE Simultaneous administration of nocistatin blocked the allodynia and hyperalgesia induced by Noc/OFQ, whereas anti-nocistatin antibody decreased the threshold for the Noc/OFQ-induced allodynia. 10998544 2000
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.340 Biomarker phenotype BEFREE Nocistatin blocks nociceptin-induced allodynia and hyperalgesia, and attenuates pain evoked by prostaglandin E2. 9521323 1998