| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.270 | Biomarker | phenotype | BEFREE | These results indicate that TLR4 may play a major role in regulation of TRPV1 signaling and peripheral hyperalgesia in inflammatory conditions. | 30672380 | 2019 | ||||
|
0.270 | Biomarker | phenotype | BEFREE | Intrathecal oligodeoxynucleotide antisense to TLR4 mRNA (TLR4 AS-ODN) prevented OIH and prolongation of prostaglandin E<sub>2</sub> hyperalgesia (priming) induced by LDM. | 31209174 | 2019 | ||||
|
0.270 | Biomarker | phenotype | BEFREE | The present study examined whether elements of the TLR4 pathway contribute to hyperalgesia induced by dural inflammation in rats. | 29310498 | 2018 | ||||
|
0.270 | Biomarker | phenotype | BEFREE | These results suggest that TLR4 participates in the spread of allodynia component of orofacial pain to distant body sites, but not trigeminal neuropathic pain or the spread of its hyperalgesia component. | 29112008 | 2018 | ||||
|
0.270 | Biomarker | phenotype | BEFREE | The aim of this study was to determine whether mice without the Tlr4 gene (Tlr4) would not develop remifentanil-induced hyperalgesia. | 29538008 | 2018 | ||||
|
0.270 | Biomarker | phenotype | BEFREE | Intrathecal administration of LvOn‑si‑TLR4 with doxycycline (Dox) attenuated allodynia and hyperalgesia. | 30365084 | 2018 | ||||
|
0.270 | Biomarker | phenotype | BEFREE | Rats were intrathecally infused with bLF, lipopolysaccharide from Rhodobacter sphaeroides (LPS-RS), an antagonist of Toll-like receptor 4 (TLR4), or interleukin (IL)-18 binding protein (BP). bLF attenuated allodynia/hyperalgesia and blocked upregulation of phosphorylated (p)-p38 mitogen-activated protein kinase (MAPK), p-nuclear factor (NF)-κB p65, p-IκB kinase, and IL-18 in the trigeminal subnucleus caudalis (Vc). | 28465227 | 2017 | ||||
|
0.270 | Biomarker | phenotype | RGD | Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain. | 20714435 | 2010 |