Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1581
Gene Symbol: CYP7A1
CYP7A1
0.700 GeneticVariation disease BEFREE The CYP7A1 gene polymorphism rs3824260 is related to inappropriate response of simvastatin treatment for hypercholesterolemia patients in Chinese Han population. 31663874 2020
Entrez Id: 1581
Gene Symbol: CYP7A1
CYP7A1
0.700 AlteredExpression disease BEFREE The ACAT-2 and CYP7A1 mRNA expression were significantly decreased in HC diet supplemented with STG, while the mRNA levels of LDLR were markedly increased. 30937311 2019
Entrez Id: 1581
Gene Symbol: CYP7A1
CYP7A1
0.700 Biomarker disease BEFREE In addition, manipulating BA homeostasis by modulating cholesterol 7α-hydroxylase (CYP7A1) may affect the metabolic processing of cholesterol, exerting therapeutic effects on hypercholesterolemia and cardiovascular diseases. 30978324 2019
Entrez Id: 1581
Gene Symbol: CYP7A1
CYP7A1
0.700 GeneticVariation disease BEFREE Collectively, these results indicate that atRA activates JNK and ERK pathways and the downstream target AP-1 represses HNF4α transactivation of the CYP7A1 promoter, potentially responsible for hypercholesterolemia. 30709899 2019
Entrez Id: 1581
Gene Symbol: CYP7A1
CYP7A1
0.700 AlteredExpression disease BEFREE Moreover, BS were capable of down-regulating CYP7A1 expression in MTs and elicited abnormal lipid production (accumulation) concordant with clinical cases where chronic cholestasis results in hypercholesterolemia. 31195089 2019
Entrez Id: 1581
Gene Symbol: CYP7A1
CYP7A1
0.700 Biomarker disease BEFREE The findings of the present study provide a positive role of ML on cholesterol clearance via promoting cholesterol and TBA execration via FXR- and CYP7A1-mediated pathways; RCT regulation may be a potential mechanism of ML on anti-hypercholesterolemia. 30116313 2018
Entrez Id: 1581
Gene Symbol: CYP7A1
CYP7A1
0.700 AlteredExpression disease BEFREE EP4 deficiency negatively regulate bile acid synthesis through repression of phosphorylated extracellular signal-regulated kinase 1/2 (ERK)-mediated cholesterol 7α-hydroxylase (CYP7A1) expression and that the hypercholesterolemia in EP4 knockout mice is due to a defect in cholesterol conversion into bile acids. 29890224 2018
Entrez Id: 1581
Gene Symbol: CYP7A1
CYP7A1
0.700 Biomarker disease BEFREE Appraisal of the liver revealed an up-regulation of mRNA expressions of the small heterodimer partner (Shp) and attenuation of Cyp7a1, which contributed to hypercholesterolemia in vitamin D-deficiency. 29243851 2018
Entrez Id: 1581
Gene Symbol: CYP7A1
CYP7A1
0.700 AlteredExpression disease BEFREE Female-biased expression was also observed for CYP7A1, which is activated by drugs used to treat hypercholesterolemia. 21858147 2011
Entrez Id: 1581
Gene Symbol: CYP7A1
CYP7A1
0.700 Biomarker disease RGD Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats. 16472823 2006
Entrez Id: 1581
Gene Symbol: CYP7A1
CYP7A1
0.700 AlteredExpression disease BEFREE Mice expressing the human CYP7A1 gene in the mouse CYP7A1 knock-out background lack induction of CYP7A1 expression by cholesterol feeding and have increased hypercholesterolemia when fed a high fat diet. 12202481 2002
Entrez Id: 1581
Gene Symbol: CYP7A1
CYP7A1
0.700 Therapeutic disease CTD_human Bile acid excretion and cholesterol 7 alpha-hydroxylase expression in hypercholesterolemia-resistant rabbits. 8245718 1993
Entrez Id: 1581
Gene Symbol: CYP7A1
CYP7A1
0.700 Biomarker disease HPO