| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.550 | Biomarker | disease | BEFREE | Increased hepatic ABCA1 transporter is associated with hypercholesterolemia in a cholestatic rat model and primary biliary cholangitis patients. | 28660384 | 2017 | ||||
|
0.550 | Biomarker | disease | BEFREE | TSH increases synthesis of hepatic ATP-binding cassette subfamily A member 1 in hypercholesterolemia. | 27179782 | 2016 | ||||
|
0.550 | Biomarker | disease | CTD_human | LDL receptor knockout (KO) mice were transplanted with bone marrow from ABCA1/apoE double KO (dKO) mice, their respective single KO's, and wild-type (WT) controls and were challenged with a high-fat/high-cholesterol diet for 9 weeks. | 22022523 | 2011 | ||||
|
0.550 | GeneticVariation | disease | BEFREE | Evaluation of genotype distributions by the Chi-square test and subsequent multivariable logistic regression analysis with adjustment for age, sex, body mass index, smoking status, and the prevalence of diabetes mellitus and hypercholesterolemia revealed that the -14C-->T polymorphism of ABCA1, the C-->G (Ser2229Cys) polymorphism of ROS1, the C-->T (Asn591Asn) polymorphism of LDLR, the 13989A-->G (Ile118Val) polymorphism of CYP3A4, the C-->G and A-->C polymorphisms of ADIPOR1, and the -519A-->G polymorphism of MMP1 were significantly (P<0.05) associated with the prevalence of hypertension. | 18097620 | 2008 | ||||
|
0.550 | AlteredExpression | disease | LHGDN | Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1. | 15851589 | 2005 | ||||
|
0.550 | AlteredExpression | disease | BEFREE | These combined results indicate that overexpression of ABCA1 in C57BL/6 mice on a high cholesterol diet results in an atheroprotective lipoprotein profile and decreased atherosclerosis, and thus provide previously undocumented in vivo evidence of an anti-atherogenic role for the ABCA1 transporter. | 11752403 | 2002 | ||||
|
0.550 | Biomarker | disease | GENOMICS_ENGLAND |